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Review
. 2021 Apr;41(2):117-122.
doi: 10.1080/10799893.2020.1806315. Epub 2020 Aug 18.

Research progress in the mechanism of calcium ion on contraction and relaxation of airway smooth muscle cells

Xiyu Du  1 , Juan Zhi  1 , Dong Yang  1 , Qianyu Wang  1 , Xiang Luo  1 , Xiaoming Deng  1
Affiliations
Review

Research progress in the mechanism of calcium ion on contraction and relaxation of airway smooth muscle cells

Xiyu Du et al. J Recept Signal Transduct Res. 2021 Apr.

Abstract

lntracellular calcium ion is the key secondary messenger system of the cellular processes in airway smooth muscle cells(ASMc). The treatment and regulation of Ca2+ in airway smooth muscle (ASM) is, in part, to associated with many airway diseases such as asthma, COPD and pulmonary fibrosis. The mechanism of contraction and relaxation of ASM is a concerned aspect in airway diseases. This review emphasizes established and recent discoveries whice show the research progress of Ca2+ on cell contraction and relaxation in ASM in recent years, to provide theoretical support and new targets for clinical prevention and treatment of perioperative bronchospasm and variousrespiratory related diseases.

Keywords: +); (Ca2; Calcium ion; airway smooth muscle cells; calcium oscillations; contraction; relaxation.

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