Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection

doi:10.1007/s00415-020-10164-3

. 2021 May;268(5):1592-1594.

doi: 10.1007/s00415-020-10164-3. Epub 2020 Aug 18.

Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection

Anthony Moreau¹, Amedee Ego², Frederic Vandergheynst³, Fabio Silvio Taccone², Niloufar Sadeghi⁴, Isabel Montesinos⁵, Nicolas Gaspard^{6

7}, Julie Gorham²

Affiliations

¹ Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium. Anthony.Moreau@ulb.be.
² Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.
³ Department of Internal Medicine, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
⁴ Department of Neuroradiology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
⁵ Microbiology Department, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), Université Libre de Bruxelles, Brussels, Belgium.
⁶ Department of Neurology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
⁷ Department of Neurology, Yale University, New Haven, CT, USA.

PMID: 32809154
PMCID: PMC7433277
DOI: 10.1007/s00415-020-10164-3

Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection

Anthony Moreau et al. J Neurol. 2021 May.

. 2021 May;268(5):1592-1594.

doi: 10.1007/s00415-020-10164-3. Epub 2020 Aug 18.

Authors

Anthony Moreau¹, Amedee Ego², Frederic Vandergheynst³, Fabio Silvio Taccone², Niloufar Sadeghi⁴, Isabel Montesinos⁵, Nicolas Gaspard^{6

7}, Julie Gorham²

Affiliations

¹ Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium. Anthony.Moreau@ulb.be.
² Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.
³ Department of Internal Medicine, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
⁴ Department of Neuroradiology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
⁵ Microbiology Department, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), Université Libre de Bruxelles, Brussels, Belgium.
⁶ Department of Neurology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
⁷ Department of Neurology, Yale University, New Haven, CT, USA.

PMID: 32809154
PMCID: PMC7433277
DOI: 10.1007/s00415-020-10164-3

No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

**Fig. 1**
Brain magnetic resonance imaging (MRI), performed the day after admission, revealed the presence of a well-circumscribed oval lesion within the splenium of the corpus callosum. The lesion demonstrates the features of cytotoxic edema: hyperintensity in fluid-attenuation inversion recovery (FLAIR) sequence (a) and restricted diffusion displayed by an area of high signal intensity on diffusion-weighted imaging (DWI; b) and low signal intensity on apparent diffusion coefficient (ADC; c) map. There is no hemorrhage on gradient echo T2-weighted imaging (d). Control MRI showed complete resolution of the lesion on FLAIR (e) and DWI (f) sequences

See this image and copyright information in PMC

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References

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[1] Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in china, 2019. N Engl J Med. 2020;382(8):727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed

[2] Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in china, 2019. N Engl J Med. 2020;382(8):727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed

[3] Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020 doi: 10.1001/jamaneurol.2020.1127. - DOI - PMC - PubMed

[4] Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020 doi: 10.1001/jamaneurol.2020.1127. - DOI - PMC - PubMed

[5] Tetsuka S. Reversible lesion in the splenium of the corpus callosum. Brain Behav. 2019;9(11):e01440. doi: 10.1002/brb3.1440. - DOI - PMC - PubMed

[6] Tetsuka S. Reversible lesion in the splenium of the corpus callosum. Brain Behav. 2019;9(11):e01440. doi: 10.1002/brb3.1440. - DOI - PMC - PubMed

[7] Ruan Q, Yang K, Wang W, et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46:846–848. doi: 10.1007/s00134-020-05991-x. - DOI - PMC - PubMed

[8] Ruan Q, Yang K, Wang W, et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46:846–848. doi: 10.1007/s00134-020-05991-x. - DOI - PMC - PubMed

[9] Sethuraman N, Jeremiah SS, Ryo A. Interpreting diagnostic tests for SARS-CoV-2. JAMA. 2020 doi: 10.1001/jama.2020.8259. - DOI - PubMed

[10] Sethuraman N, Jeremiah SS, Ryo A. Interpreting diagnostic tests for SARS-CoV-2. JAMA. 2020 doi: 10.1001/jama.2020.8259. - DOI - PubMed

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Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection

Affiliations

Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection

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Conflict of interest statement

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