Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Adult Diabetic Ketoacidosis

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Adult Diabetic Ketoacidosis

Jenna M. Lizzo et al.
Free Books & Documents

Excerpt

Diabetic ketoacidosis (DKA) represents a critical metabolic emergency marked by hyperglycemia, acidosis, and ketonemia. Although most frequently associated with type 1 diabetes, the condition can also affect individuals with type 2 diabetes under certain circumstances. The severity of DKA stems from its rapid onset and potential to cause significant morbidity and mortality if unrecognized or untreated.

The development of DKA commonly results from new-onset diabetes, underlying infections, or poor adherence to therapy. Additional stressors such as acute illness, trauma, or medication effects may also precipitate the condition. Early identification and prompt management remain essential, as timely intervention greatly improves patient outcomes.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Jenna Lizzo declares no relevant financial relationships with ineligible companies.

Disclosure: Amandeep Goyal declares no relevant financial relationships with ineligible companies.

Disclosure: Jasleen Kaur declares no relevant financial relationships with ineligible companies.

References

    1. Karslioglu French E, Donihi AC, Korytkowski MT. Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients. BMJ. 2019 May 29;365:l1114. - PubMed
    1. Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009 Jul;32(7):1335-43. - PMC - PubMed
    1. Chow E, Clement S, Garg R. Euglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors. BMJ Open Diabetes Res Care. 2023 Oct;11(5) - PMC - PubMed
    1. Rawla P, Vellipuram AR, Bandaru SS, Pradeep Raj J. Euglycemic diabetic ketoacidosis: a diagnostic and therapeutic dilemma. Endocrinol Diabetes Metab Case Rep. 2017;2017 - PMC - PubMed
    1. Taylor SI, Blau JE, Rother KI. SGLT2 Inhibitors May Predispose to Ketoacidosis. J Clin Endocrinol Metab. 2015 Aug;100(8):2849-52. - PMC - PubMed

Publication types

LinkOut - more resources