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Book

Fosphenytoin

Rozaleen Aleyadeh  1 , Robert P. Carson  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Fosphenytoin

Rozaleen Aleyadeh et al.
Free Books & Documents

Excerpt

Fosphenytoin is a medication used to manage seizures (treatment of generalized tonic-clonic status epilepticus, focal [partial] onset seizures, or generalized onset seizures, and for the prevention and treatment of seizures occurring during neurosurgery). It is a water-soluble phenytoin prodrug that can be employed in situations where phenytoin use is not advisable. It is in the hydantoin anticonvulsant class of medications. This activity outlines the indications, action, and contraindications for fosphenytoin as a valuable agent for neurosurgery prophylaxis, short-term oral phenytoin substitute, and treatment for status epilepticus. This activity will highlight the mechanism of action, adverse event profile, off-label use, and monitoring pertinent for healthcare team members in managing patients with seizures and related conditions.

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Conflict of interest statement

Disclosure: Rozaleen Aleyadeh declares no relevant financial relationships with ineligible companies.

Disclosure: Robert Carson declares no relevant financial relationships with ineligible companies.

References

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