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Book

Postoperative Ileus

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Postoperative Ileus

Lucas Buchanan et al.
Free Books & Documents

Excerpt

Postoperative ileus is an abnormal pattern of slow or absent gastrointestinal motility in response to surgical procedures. Clinically, it is manifested by intolerance of oral intake and abdominal distention due to inhibition of the gastrointestinal propulsion without signs of mechanical obstruction. Generally, patients undergoing an abdominal surgical procedure will develop some degree of transient impairment of gastrointestinal motility. Often, this is an uncomplicated sequela with little consequence. Some surgeons consider it as a normal physiologic response of the intestine to surgery.

Prolonged impairment, however, can lead to several considerable impediments, including increased hospital stay, healthcare costs, and patient discomfort. It is estimated that the economic impact of postoperative ileus is approximately 750 million dollars annually in the United States alone. The significance of postoperative ileus is that it simulates other serious complications like bowel obstruction, and it delays recovery. Therefore, optimizing measures to prevent and/or treat it appropriately after excluding other complications is imperative to consider.

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Conflict of interest statement

Disclosure: Lucas Buchanan declares no relevant financial relationships with ineligible companies.

Disclosure: Faiz Tuma declares no relevant financial relationships with ineligible companies.

References

    1. Venara A, Neunlist M, Slim K, Barbieux J, Colas PA, Hamy A, Meurette G. Postoperative ileus: Pathophysiology, incidence, and prevention. J Visc Surg. 2016 Dec;153(6):439-446. - PubMed
    1. Vather R, Trivedi S, Bissett I. Defining postoperative ileus: results of a systematic review and global survey. J Gastrointest Surg. 2013 May;17(5):962-72. - PubMed
    1. Vather R, O'Grady G, Bissett IP, Dinning PG. Postoperative ileus: mechanisms and future directions for research. Clin Exp Pharmacol Physiol. 2014 May;41(5):358-70. - PubMed
    1. Stakenborg N, Gomez-Pinilla PJ, Boeckxstaens GE. Postoperative Ileus: Pathophysiology, Current Therapeutic Approaches. Handb Exp Pharmacol. 2017;239:39-57. - PubMed
    1. Senagore AJ. Pathogenesis and clinical and economic consequences of postoperative ileus. Am J Health Syst Pharm. 2007 Oct 15;64(20 Suppl 13):S3-7. - PubMed

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