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. 2020 Sep:59:102938.
doi: 10.1016/j.ebiom.2020.102938. Epub 2020 Aug 15.

Therapeutic potential of tricarboxylic acid cycle metabolite itaconate in cardiovascular diseases

Chongzhe Yang  1 , Tianxiao Liu  2 , Guo-Ping Shi  3
Affiliations

Therapeutic potential of tricarboxylic acid cycle metabolite itaconate in cardiovascular diseases

Chongzhe Yang et al. EBioMedicine. 2020 Sep.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The author declares no conflicts of interest.

Figures

Fig 1
Fig. 1
LPS and interferons induce IRG1 expression and itaconate production from the TAC cycle. Itaconate and its derivatives DI and OI contribute to (1) succinate dehydrogenase inhibition and succinate accumulation; (2) KEAP1 cysteine alkylation, Nrf2 expression and nucleus translocation, and pro- and anti-inflammatory molecule expression regulation; (3) ATF3 expression; and (4) M2 macrophage polarization.
See this image and copyright information in PMC

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