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. 2020 Nov;40(11):1634-1643.
doi: 10.1038/s41372-020-00788-8. Epub 2020 Aug 18.

Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension

Mitali Sahni  1   2 , Bettie Yeboah  2 , Pragnya Das  2   3 , Dilip Shah  2   3 , Devasena Ponnalagu  4 , Harpreet Singh  4 , Leif D Nelin  5 , Vineet Bhandari  6   7
Affiliations

Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension

Mitali Sahni et al. J Perinatol. 2020 Nov.

Abstract

Objective: To quantify and compare levels of potential biomarkers in neonates with (i) Bronchopulmonary dysplasia (BPD); (ii) BPD-associated pulmonary hypertension (BPD-PH); (iii) PH without BPD; and (iv) neonates without lung disease at ~36 weeks postmenstrual age.

Study design: Multiple potential biomarkers were measured in plasma samples of 90 patients using a multi-spot enzyme-linked immunosorbent assay. Statistical tests done included one-way ANOVA to compare levels of biomarkers between different groups.

Results: Higher levels of ICAM-1 were present in infants with BPD and correlated with its severity. Infants with BPD have significantly higher levels of ANG-2 and lower levels of ANG-1. Infants with PH have higher levels of: IL-6, IL-8, IL-10, and TNF-α. Infants with BPD-PH have significantly lower levels of MCP-1 and higher levels of IL-1β than infants with PH without BPD.

Conclusion: ICAM-1 may be used as a specific biomarker for diagnosis of BPD and its severity.

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Conflict of interest statement

Conflicts of Interest: The authors declare no conflicts of interest.

Figures

Figure 1-
Figure 1-
Biomarkers in PC, TC, BPD, PHTN and BPD-PH (Discovery cohort): A)Elevated levels of ICAM-1 as compared to PC, TC and BPD-PH. ICAM levels also correlate with severity of BPD (p=0.0047). B) Infants with BPD have higher level of Ang2 and lower level of Ang1.
Figure 2-
Figure 2-
Biomarkers in PC, TC, BPD, PHTN and BPD-PH (Discovery cohort): A) Higher levels of IL-1β and lower level of MCP-1 were seen in BPD-PH as compared to PHTN and, TC.
Figure 3-
Figure 3-
Biomarkers in PC, TC, BPD, PHTN and BPD-PH (Discovery cohort): Specific cytokines (IL6, IL8, IL10 and TNFα) were significantly increased in infants with PH, compared to TC.
Figure 4-
Figure 4-
Biomarkers in BPD (validation cohort vs. discovery cohort): A)Elevated levels of ICAM-1 in both BPD groups as compared to PC. B, C & D) Higher levels of IL-1β, IL-6 and TNF-α in BPD-NW as compared to BPD-SC and PC. E) Lower levels of IL-8 in BPD-NW as compared to BPD-SC.
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