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. 2020 Nov 9;222(11):1789-1793.
doi: 10.1093/infdis/jiaa528.

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Christophe Guervilly  1   2 , Stephane Burtey  3   4 , Florence Sabatier  4   5   6 , Raphaël Cauchois  4   7 , Guillaume Lano  3   4 , Evelyne Abdili  5 , Florence Daviet  3 , Laurent Arnaud  5 , Philippe Brunet  3   4 , Sami Hraiech  1   2 , Noémie Jourde-Chiche  3   4 , Marie Koubi  7 , Romaric Lacroix  4   5 , Léa Pietri  8 , Yaël Berda  5 , Thomas Robert  3   4 , Clara Degioanni  6 , Mélanie Velier  4   5 , Laurent Papazian  1   2 , Gilles Kaplanski  4   7 , Françoise Dignat-George  4   5
Affiliations

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Christophe Guervilly et al. J Infect Dis. .

Abstract

Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.

Keywords: COVID-19; circulating endothelial cells; endothelial injury.

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