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Comment
. 2020 Aug 18;53(2):235-237.
doi: 10.1016/j.immuni.2020.07.016.

Scratching Beyond the Surface of Itchy Wounds

Ting-Lin B Yang  1 , Brian S Kim  2
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Scratching Beyond the Surface of Itchy Wounds

Ting-Lin B Yang et al. Immunity. .
Free article

Abstract

In this issue of Immunity, Xu et al. reveal that dermal dendritic cells produce interleukin-31, which acts on neurons to promote wound itch. Their findings link itch associated with deeper wounds-wounds that extend beyond the epithelium-to the cells and cytokines that mediate wound healing.

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Conflict of interest statement

Declaration of Interests B.S.K. has served as a consultant for AbbVie, Cara Therapeutics, Concert Pharmaceuticals, Incyte Corporation, LEO Pharma, Menlo Therapeutics, and Pfizer. He has also participated on the advisory board for Cara Therapeutics, Celgene Corporation, Kiniksa Pharmaceuticals, Menlo Therapeutics, Regeneron Pharmaceuticals, Sanofi Genzyme, Theravance Biopharma, and Trevi Therapeutics. He is also the founder, chief scientific officer, and stockholder of Nuogen Pharma and a stockholder of Locus Biosciences. He has a patent pending for the use of JAK inhibitors for chronic itch. T.B.Y. declares no competing interests.

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