Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov:63:101146.
doi: 10.1016/j.arr.2020.101146. Epub 2020 Aug 16.

Behavioral and Social Research to Accelerate the Geroscience Translation Agenda

Terrie E Moffitt  1
Affiliations

Behavioral and Social Research to Accelerate the Geroscience Translation Agenda

Terrie E Moffitt. Ageing Res Rev. 2020 Nov.

Abstract

Geroscience is the study of how to slow biological aging to extend healthspan and longevity. Geroscience has not heretofore incorporated behavioral or social-science methods or findings into its agenda, but the current expansion of the agenda to human trials of anti-aging therapies will be greatly aided by behavioral and social science. This article recommends some ways in which geroscience can be augmented through collaboration with behavioral and social science to: accomplish translation from animal models to humans; inform the design of clinical trials of anti-aging therapies; develop outcome measures for evaluating efficacy of anti-aging therapies, and reduce and not exacerbate health disparities.

Keywords: Geroscience; behavioral; clinical trials; epigenetic; health disparities; social; translation.

PubMed Disclaimer

References

    1. Abraha I, Cozzolino F, Orso M, Marchesi M, Germani A, Lombardo G, Eusebi P, De Florio R, Luchetta ML, Iorio A, Montedori A. (2017). A systematic review found that deviations for intention-to-treat are common in randomized trials and systematic reviews. J Clin Epidemiol, 84, 37–46. doi: 10.1016/j.jclinepi.2016.11.012 - DOI - PubMed
    1. Barzilai N, Cuervo AM, Austad S. (2018). Aging as a biological target for prevention and therapy. JAMA. 320(13):1321–1322. doi:10.1001/jama.2018.9562 - DOI - PubMed
    1. Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington HL, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R Moffitt TE (2015) Quantification of biological aging in young adults. Proceedings of the National Academy of Sciences,112 (30) E4104–E4110; DOI: 10.1073/pnas.1506264112 - DOI - PMC - PubMed
    1. Belsky DW, Caspi A, Cohen HJ, Kraus WE, Ramrakha S, Poulton R, Moffitt TE. (2017) Impact of early personal‐history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. Aging Cell, 644–651. Doi:10.1111/acel.12591. - DOI - PMC - PubMed
    1. Belsky DW, Moffitt TW, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A (2018). Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: Do they measure the same thing? American Journal of Epidemiology, Volume 187, Issue 6, Pages 1220–1230, 10.1093/aje/kwx346 - DOI - PMC - PubMed

Publication types