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. 2021 Feb;48(2):570-579.
doi: 10.1007/s00259-020-04996-4. Epub 2020 Aug 19.

2-[18F]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma

Yanyan Zhao #  1 , Caixia Wu #  1 , Wei Li #  2 , Xueqi Chen  1 , Ziao Li  3 , Xuhe Liao  1 , Yonggang Cui  1 , Guangyu Zhao  1 , Meng Liu  4 , Zhanli Fu  5
Affiliations

2-[18F]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma

Yanyan Zhao et al. Eur J Nucl Med Mol Imaging. 2021 Feb.

Abstract

Purpose: To explore the potential parameters from preoperative 2-[18F]FDG PET/CT that might associate with the World Health Organization/the International Society of Urological Pathology (WHO/ISUP) grade in clear cell renal cell carcinoma (ccRCC).

Methods: One hundred twenty-five patients with newly diagnosed ccRCC who underwent 2-[18F]FDG PET/CT prior to surgery or biopsy were retrospectively reviewed. The metabolic parameters and imaging features obtained from 2-[18F]FDG PET/CT examinations were analyzed in combination with clinical characteristics. Univariate and multivariate logistic regression analyses were performed to identify the predictive factors of WHO/ISUP grade.

Results: Metabolic parameters of primary tumor maximum standardized uptake value (SUVmax), tumor-to-liver SUV ratio (TLR), and tumor-to-kidney SUV ratio (TKR) were significantly different between any two of the four different WHO/ISUP grades, except those between the WHO/ISUP grade 3 and grade 4. The optimal cutoff values to predict high WHO/ISUP grade for SUVmax, TLR, and TKR were 4.15, 1.63, and 1.59, respectively. TLR (AUC: 0.841) was superior to TKR (AUC: 0.810) in distinguishing high and low WHO/ISUP grades (P = 0.0042). In univariate analysis, SUVmax, TLR, TKR, primary tumor size, tumor thrombus, distant metastases, and clinical symptoms could discriminate between the high and low WHO/ISUP grades (P < 0.05). In multivariate analysis, TLR (P < 0.001; OR: 1.732; 95%CI: 1.289-2.328) and tumor thrombus (P < 0.001; OR: 6.199; 95%CI: 2.499-15.375) were significant factors for differentiating WHO/ISUP grades.

Conclusion: Elevated TLR (> 1.63) and presence of tumor thrombus from preoperative 2-[18F]FDG PET/CT can distinguish high WHO/ISUP grade ccRCC effectively. 2-[18F]FDG PET/CT may be a feasible method for noninvasive assessment of WHO/ISUP grade.

Keywords: 2-[18F]FDG PET/CT; Clear cell renal cell carcinoma (ccRCC); Tumor thrombus; Tumor-to-liver standardized uptake value ratio (TLR); World Health Organization/the International Society of Urological Pathology (WHO/ISUP) grade.

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References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30. https://doi.org/10.3322/caac.21590 . - DOI
    1. Dagher J, Delahunt B, Rioux-Leclercq N, Egevad L, Srigley JR, Coughlin G, et al. Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. Histopathology. 2017;71(6):918–25. https://doi.org/10.1111/his.13311 . - DOI - PubMed
    1. Moch H. The WHO/ISUP grading system for renal carcinoma. Pathologe. 2016;37(4):355–60. https://doi.org/10.1007/s00292-016-0171-y . - DOI - PubMed
    1. Kim H, Inomoto C, Uchida T, Furuya H, Komiyama T, Kajiwara H, et al. Verification of the international society of urological pathology recommendations in Japanese patients with clear cell renal cell carcinoma. Int J Oncol. 2018;52(4):1139–48. https://doi.org/10.3892/ijo.2018.4294 . - DOI - PubMed - PMC
    1. Leveridge MJ, Finelli A, Kachura JR, Evans A, Chung H, Shiff DA, et al. Outcomes of small renal mass needle core biopsy, nondiagnostic percutaneous biopsy, and the role of repeat biopsy. Eur Urol. 2011;60(3):578–84. https://doi.org/10.1016/j.eururo.2011.06.021 . - DOI - PubMed

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