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. 2021 Jan;31(1):260-266.
doi: 10.1007/s11695-020-04909-2. Epub 2020 Aug 20.

Bariatric Surgery Improves Renal Function: a Large Inner-City Population Outcome Study

Kashif Saeed  1 , Leaque Ahmed  2   3 , Paritosh Suman  3 , Sanjiv Gray  4 , Khuram Khan  3 , Hector DePaz  3 , Amrita Persaud  3 , Bianca Passos Fox  3 , Sara Alothman  2 , Saqib Saeed  5
Affiliations

Bariatric Surgery Improves Renal Function: a Large Inner-City Population Outcome Study

Kashif Saeed et al. Obes Surg. 2021 Jan.

Abstract

Background: Bariatric surgery is associated with improved renal dysfunction in general population studies. The study examined the effects of bariatric surgery on renal function in a predominantly Hispanic and African American population at a community hospital in New York, USA.

Methods: This retrospective study analyzed prospectively collected bariatric surgical data from 2247 patients (89% female) who underwent bariatric surgery at a single center. Changes in glomerular filtration rate (eGFR), urine albumin-creatinine ratio (UACR), micro- and macroalbuminuria, and hyperfiltration, which were measured preoperatively and then yearly for 3 years postoperatively, were evaluated with t tests and logistic regression analysis, after adjusting for confounding variables. The mean age of the patients at surgery was 37.1 years; the mean preoperative body mass index was 45 ± 7 kg/m2.

Results: The results obtained 3 years postoperatively showed the following significant improvements compared with the preoperative values: mean UACR decreased from 40.3 to 11.1 mg/g, mean eGFR improved from 79.4 to 87.3 mL/min, the prevalence of microalbuminuria decreased from 13.7 to 6.2%, the prevalence of macroalbuminuria decreased from 2.5 to 0%, and the prevalence of hyperfiltration decreased from 4.4 to 2.7% (all P < .0001). In adjusted multivariate regression analysis, these results remained significant after adjusting for age, sex, race, type of surgery, and presence of diabetes mellitus or hypertension.

Conclusion: In this large study at an inner-city hospital, bariatric surgery was associated with significant improvements in renal dysfunction parameters. These results could assist with informed decisions regarding indications for bariatric surgery.

Keywords: Bariatric surgery, renal function, glomerulopathy; Chronic kidney disease; Obesity.

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