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Multicenter Study
. 2021 Apr;12(4):516-526.
doi: 10.1111/jdi.13390. Epub 2020 Oct 4.

Type 1 diabetes management and outcomes: A multicenter study in Thailand

Prapai Dejkhamron  1   2 , Jeerunda Santiprabhob  3   4 , Supawadee Likitmaskul  3   4 , Chaicharn Deerochanawong  5 , Petch Rawdaree  6 , Thipaporn Tharavanij  7   8 , Sirimon Reutrakul  9 , Chawkaew Kongkanka  10 , Chittiwat Suprasongsin  11 , Nawaporn Numbenjapon  12 , Taninee Sahakitrungruang  13 , Raweewan Lertwattanarak  3   14 , Pontipa Engkakul  15 , Apiradee Sriwijitkamol  3   14 , Manassawee Korwutthikulrangsri  16 , Rattana Leelawattana  17 , Mattabhorn Phimphilai  2   18 , Somkiat Potisat  19 , Panthep Khananuraksa  20 , Cherdchai Nopmaneejumruslers  3 , Wannee Nitiyanant  3   14 ; Thai Type 1 Diabetes and Diabetes Diagnosed Before Age 30 Years Registry, Care, and Network (T1DDAR CN)
Affiliations
Multicenter Study

Type 1 diabetes management and outcomes: A multicenter study in Thailand

Prapai Dejkhamron et al. J Diabetes Investig. 2021 Apr.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] J Diabetes Investig. 2022 Apr;13(4):749. doi: 10.1111/jdi.13794. J Diabetes Investig. 2022. PMID: 35438844 Free PMC article. No abstract available.

Abstract

Aims/introduction: The Thai Type 1 Diabetes and Diabetes Diagnosed Before Age 30 Years Registry, Care and Network was established in 2014 and involved 31 hospitals. The objective of the registry was to evaluate glycemic control and complications of patients with type 1 diabetes.

Materials and methods: Patients' demographics, clinical data, frequencies of daily self-monitoring of blood glucose (SMBG), glycemic control and complications were collected.

Results: Among the 1,907 type 1 diabetes patients, the mean age was 21.2 ± 11.3 years. The mean glycated hemoglobin level was 9.35 ± 2.41%, with significant variations among age groups (P < 0.001). Conventional insulin treatment and intensive insulin treatment were used in 43 and 57% of patients, respectively. Mean glycated hemoglobin levels were significantly higher in patients treated with conventional insulin treatment compared to those treated with intensive insulin treatment (9.63 ± 2.34 vs 9.17 ± 2.46%, P = 0.002). Compared to the conventional insulin treatment group, significantly more patients in the intensive insulin treatment group achieved good glycemic control (P < 0.001), and fewer had diabetic retinopathy (P = 0.031). The prevalence of microvascular complications increased significantly with age (P < 0.001). Multivariate analysis showed good glycemic control to be associated with age 25 to <45 years, intensive insulin treatment with SMBG three or more times daily and diabetes duration of 1 to <5 years.

Conclusions: Most Thai type 1 diabetes patients were not meeting the recommended glycemic target. As a result of this study, the national program to improve the quality of diabetes treatment and education has been implemented, and the results are ongoing.

Keywords: Intensive insulin treatment; Multiple daily insulin injection; Type 1 diabetes mellitus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Mean glycated hemoglobin (HbA1c) of 1,820 patients with type 1 diabetes stratified by age. (b) Percentage of patients achieving HbA1c targets stratified by age group. The HbA1c target for those aged <18 years was <7.5%, and the HbA1c target for those aged ≥18 years was <7.0%. CI, confidence interval; DM, diabetes mellitus.
Figure 2
Figure 2
Frequency of self‐monitoring of blood glucose (SMBG) relative to glycated hemoglobin (HbA1c) among patients with type 1 diabetes.
See this image and copyright information in PMC

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