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. 2020 Aug 3;3(8):e2013793.
doi: 10.1001/jamanetworkopen.2020.13793.

Associations Between Longitudinal Trajectories of Cognitive and Social Activities and Brain Health in Old Age

Melis Anatürk  1   2   3 , Sana Suri  1   4 , Eniko Zsoldos  1   2   3 , Nicola Filippini  1   2   3 , Abda Mahmood  1 , Archana Singh-Manoux  5   6 , Mika Kivimäki  5 , Clare E Mackay  1   4 , Klaus P Ebmeier  1 , Claire E Sexton  1   4
Affiliations

Associations Between Longitudinal Trajectories of Cognitive and Social Activities and Brain Health in Old Age

Melis Anatürk et al. JAMA Netw Open. .

Abstract

Importance: Prior neuroimaging studies have found that late-life participation in cognitive (eg, reading) and social (eg, visiting friends and family) leisure activities are associated with magnetic resonance imaging (MRI) markers of the aging brain, but little is known about the neural and cognitive correlates of changes in leisure activities during the life span.

Objectives: To examine trajectories of cognitive and social activities from midlife to late life and evaluate whether these trajectories are associated with brain structure, functional connectivity, and cognition.

Design, setting, and participants: This prospective cohort included participants enrolled in the Whitehall II study and its MRI substudy based in the UK. Participants provided information on their leisure activities at 5 times during calendar years 1997 to 1999, 2002 to 2004, 2006, 2007 to 2009, and 2011 to 2013 and underwent MRI and cognitive battery testing from January 1, 2012, to December 31, 2016. Data analysis was performed from October 7, 2017, to July 15, 2019.

Main outcome and measures: Growth curve models and latent class growth analysis were used to identify longitudinal trajectories of cognitive and social activities. Multiple linear regression was used to evaluate associations between activity trajectories and gray matter, white matter microstructure, functional connectivity, and cognition.

Results: A total of 574 individuals (468 [81.5%] men; mean [SD] age, 69.9 [4.9] years; median Montreal Cognitive Assessment score, 28 [interquartile range, 26-28]) were included in the present analysis. During a mean (SD) of 15 (4.2) years, cognitive and social activity levels increased during midlife before reaching a plateau in late life. Both baseline (global cognition: unstandardized β [SE], 0.955 [0.285], uncorrected P = .001; executive function: β [SE], 1.831 [0.499], uncorrected P < .001; memory: β [SE], 1.394 [0.550], uncorrected P = .01; processing speed: β [SE], 1.514 [0.528], uncorrected P = .004) and change (global cognition: β [SE], -1.382 [0.492], uncorrected P = .005, executive function: β [SE], -2.219 [0.865], uncorrected P = .01; memory: β [SE], -2.355 [0.948], uncorrected P = .01) in cognitive activities were associated with multiple domains of cognition as well as global gray matter volume (β [SE], -0.910 [0.388], uncorrected P = .02). Baseline (β [SE], 1.695 [0.525], uncorrected P = .001) and change (β [SE], 2.542 [1.026], uncorrected P = .01) in social activities were associated only with executive function, in addition to voxelwise measures of functional connectivity that involved sensorimotor (quadratic change in social activities: number of voxels, 306; P = 0.01) and temporoparietal (linear change in social activities: number of voxels, 16; P = .02) networks. Otherwise, no voxelwise associations were found with gray matter, white matter, or resting-state functional connectivity. False discovery rate corrections for multiple comparisons suggested that the association between cognitive activity levels and executive function was robust (β [SE], 1.831 [0.499], false discovery rate P < .001).

Conclusions and relevance: The findings suggest that a life course approach may delineate the association between leisure activities and cognitive and brain health and that interventions aimed at improving and maintaining cognitive engagement may be valuable for the cognitive health of community-dwelling older adults.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Anatürk reported receiving grants from the Clarendon Trust and the HDH Wills 1965 Charitable Trust. Dr Suri reported receiving grants from the Wellcome Centre for Integrative Neuroimaging and the UK Alzheimer’s Society. Dr Zsoldos reported receiving grants from the Wellcome Centre for Integrative Neuroimaging. Dr Filippini reported receiving grants from the NIHR Oxford Biomedical Research Centre and the NIHR Oxford Health Biomedical Research Center. Dr Mahmood reported receiving grants from the HDH Wills 1965 Charitable Trust and a PhD fellowship from the Clinical Trials Unit, Department of Population Health, London School of Hygiene and Tropical Medicine. Dr Singh-Manoux reported receiving grants from the National Institutes of Health, the UK Medical Research Council, and the British Heart Foundation. Dr Kivimäki reported receiving grants from the National Institutes of Health, the UK Medical Research Council, NordForsk, and the Academy of Finland. Dr Mackay reported receiving grants from the NIHR Oxford Biomedical Research Centre and the NIHR Oxford Health Biomedical Research Center. Dr Ebmeier reported receiving grants from the UK Medical Research Council, the HDH Wills 1965 Charitable Trust, Alzheimer Research UK, and the European Commission. Dr Sexton reported receiving grants from the NIHR Oxford Biomedical Research Centre and the NIHR Oxford Health Biomedical Research Center, personal fees from Jazz Pharmaceuticals outside the submitted work, and being a full-time employee of the Alzheimer's Association. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Means of Cognitive Activity Levels Over Time, as Estimated by the Quadratic Growth Curve Model
Data are presented as intercept coefficients. Shaded areas indicate 95% CIs.
Figure 2.
Figure 2.. Means of Social Activity Levels Over Time, as Estimated by the Quadratic Growth Curve Model
Data are presented as intercept coefficients. Shaded areas indicate 95% CIs.
Figure 3.
Figure 3.. Interaction Between Montreal Cognitive Assessment (MoCA) Scores and Cognitive Activities for Memory Scores
Data are presented as intercept coefficients (A) and quadratic coefficients (B). Unadjusted associations are presented, with shaded areas reflecting 95% CIs.
Figure 4.
Figure 4.. Results of Voxelwise Regressions Between Social Activity Trajectories and Resting-State Functional Connectivity
A, Negative correlation between quadratic coefficients of social activities and functional connectivity of the sensorimotor network. B, Negative correlation between linear coefficients of social activities and functional connectivity of the temporo-parietal network. These clusters were significant after covarying for age, sex, education, scanner, and head motion and are overlaid on spatial maps of the sensorimotor network (A) and temporo-parietal network (B) and MNI152 template. The x, y, and z coordinates are reported in MNI space (millimeters); these results did not survive false discovery rate corrections. CALC indicates intracalcarine cortex; post-CG, postcentral gyrus.
See this image and copyright information in PMC

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