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Review
. 2020 Oct 5;192(40):E1156-E1161.
doi: 10.1503/cmaj.201240. Epub 2020 Aug 16.

Anticipating and managing coagulopathy and thrombotic manifestations of severe COVID-19

Lucas C Godoy  1 , Ewan C Goligher  1 , Patrick R Lawler  2 , Arthur S Slutsky  1 , Ryan Zarychanski  1
Affiliations
Review

Anticipating and managing coagulopathy and thrombotic manifestations of severe COVID-19

Lucas C Godoy et al. CMAJ. .
No abstract available

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1:
Figure 1:
Possible mechanisms for thrombosis in coronavirus disease 2019 (COVID-19) and clinical consequences. (A) Injury to the endothelium initiated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into cells via the angiotensin-converting enzyme 2 (ACE2) receptor is thought to lead to diffuse endotheliitis. The endothelial damage may result in an inflammatory host response characterized by excessive immune activation and cytokine storm, which promotes hypercoagulability and thrombosis. (B) Possible venous and arterial thrombotic complications associated with COVID-19. Note: DVT = deep vein thrombosis, FVIIa = factor VIIA, IL-6 = interleukin 6, PE = pulmonary embolism, TF = tissue factor, TNF = tumour necrosis factor α. Original illustration by freelance medical illustrator Gail Rudakevich.
See this image and copyright information in PMC

References

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