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. 2020 Sep;26(9):2218-2222.
doi: 10.3201/eid2609.191772.

Carbapenemase-Producing Gram-Negative Bacteria in Andalusia, Spain, 2014-2018

Inmaculada López-Hernández, Mercedes Delgado-Valverde, Felipe Fernández-Cuenca, Lorena López-Cerero, Jesús Machuca, Álvaro Pascual

Carbapenemase-Producing Gram-Negative Bacteria in Andalusia, Spain, 2014-2018

Inmaculada López-Hernández et al. Emerg Infect Dis. 2020 Sep.

Abstract

The emergence and spread of carbapenemase-producing gram-negative bacteria is a major public health concern. We used data collected from microbiology laboratories as part of the PIRASOA program during 2014-2018 to study the epidemiology of carbapenemase-producing bacteria in Andalusia, Spain. Our findings highlight the importance of ongoing surveillance and epidemiologic studies for these bacteria.

Keywords: AMR; Acinetobacter baumannii; Citrobacter freundii; Enterobacter cloacae; Escherichia coli; Klebsiella oxytoca; Klebsiella pneumoniae; PIRASOA; Pseudomonas aeruginosa; Spain; antimicrobial resistance; bacteria; carbapenemases; cloxacillin; dipicolinic acid; gram-negative bacteria; molecular epidemiology; phenyl boronic acid.

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Figures

Figure 1
Figure 1
Distribution of carbapenemase types recovered in Andalusia, 2014–2018. IMP, imipenemase; KPC, Klebsiella pneumoniae carbapenemase; MBL, metallo-β-lactamases; NDM, New Delhi metallo-beta-lactamase; OXA, oxacillinases; VIM, Verona integron-encoded metallo-β-lactamase.
Figure 2
Figure 2
Characteristics of clusters of carbapenemase-producing gram negative bacteria, Andalusia, 2014–2018. Hospitals are identified by number: Almería ,1, 2, 5; Cádiz, 7, 8, 9; Córdoba, 6, 11, 12; Granada, 4, 13; Huelva, 20; Jaén, 10, 21; Málaga, 17, 18, 19; Sevilla, 3, 14, 15, 16. Ab, Acinetobacter baumannii; CTX-M, Cefotaximase-Munich; Eclo, Enterobacter cloacae; IMP, imipenemase; Kox, Klebsiella oxytoca; KPC, Klebsiella pneumoniae carbapenemase; Kpn, Klebsiella pneumoniae; MBL, metallo-β-lactamases; NDM, New Delhi metallo-beta-lactamase; OXA, oxacillinases; Pae, Pseudomonas aeruginosa; Pp, Pseudomonas putida; ST, sequence type; VIM, Verona integron-encoded metallo-β-lactamase.
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