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. 2020 Aug 29;396(10251):597-598.
doi: 10.1016/S0140-6736(20)31759-1. Epub 2020 Aug 17.

SARS-CoV-2 renal tropism associates with acute kidney injury

Fabian Braun  1 , Marc Lütgehetmann  2 , Susanne Pfefferle  2 , Milagros N Wong  1 , Alexander Carsten  2 , Maja T Lindenmeyer  1 , Dominik Nörz  2 , Fabian Heinrich  3 , Kira Meißner  3 , Dominic Wichmann  4 , Stefan Kluge  4 , Oliver Gross  5 , Klaus Pueschel  3 , Ann S Schröder  3 , Carolin Edler  3 , Martin Aepfelbacher  2 , Victor G Puelles  1 , Tobias B Huber  6
Affiliations

SARS-CoV-2 renal tropism associates with acute kidney injury

Fabian Braun et al. Lancet. .
No abstract available

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Figures

Figure
Figure
Association between SARS-CoV-2 renal tropism, disease severity, and acute kidney injury SARS-CoV-2 tropism was associated with older age and a number of coexisting conditions (A). Survival graph comparing patients with (n=19) and without (n=13) SARS-CoV-2 renal tropism (B). High frequency of SARS-CoV-2 renal tropism in patients with acute kidney injury (C). Successful isolation of infectious SARS-CoV-2 from a post-mortem kidney tissue sample (D). SARS-CoV-2=severe acute respiratory syndrome coronavirus 2. CEC=coexisting conditions. HR=hazard ratio.
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References

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    1. Batlle D, Soler MJ, Sparks MA, et al. Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology. JASN. 2020;31:1380–1383. - PMC - PubMed
    1. Kim D, Lee J-Y, Yang J-S, Kim JW, Kim VN, Chang H. The architecture of SARS-CoV-2 transcriptome. Cell. 2020;181:914–921. - PMC - PubMed

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