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Comment
. 2020 Aug 21;369(6506):919-920.
doi: 10.1126/science.abd7063.

Remodeling vasculature to avoid blindness

Eugene A Podrez  1 , Tatiana V Byzova  2
Affiliations
Comment

Remodeling vasculature to avoid blindness

Eugene A Podrez et al. Science. .
No abstract available

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Figures

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Liquid crystals from smooth curved colloidal systems
Fernández-Rico et al. found that different liquid crystals form from microrods with different degrees of curvature. Natural systems such as cellulose nanorods form liquid crystals but have a chiral nature. Cellulose-nanorod chiral nematics Solutions of cellulose nanorods form a nematic liquid crystalline phase that has a chiral twist. Long-curved flaments Similar structures are formed in certain liquid crystal phases.
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Liquid crystals from smooth curved colloidal systems
Fernández-Rico et al. found that different liquid crystals form from microrods with different degrees of curvature. Natural systems such as cellulose nanorods form liquid crystals but have a chiral nature. Cellulose-nanorod chiral nematics Solutions of cellulose nanorods form a nematic liquid crystalline phase that has a chiral twist. Long-curved flaments Similar structures are formed in certain liquid crystal phases.
None
Liquid crystals from smooth curved colloidal systems
Fernández-Rico et al. found that different liquid crystals form from microrods with different degrees of curvature. Natural systems such as cellulose nanorods form liquid crystals but have a chiral nature. Cellulose-nanorod chiral nematics Solutions of cellulose nanorods form a nematic liquid crystalline phase that has a chiral twist. Long-curved flaments Similar structures are formed in certain liquid crystal phases.
None
Liquid crystals from smooth curved colloidal systems
Fernández-Rico et al. found that different liquid crystals form from microrods with different degrees of curvature. Natural systems such as cellulose nanorods form liquid crystals but have a chiral nature. Cellulose-nanorod chiral nematics Solutions of cellulose nanorods form a nematic liquid crystalline phase that has a chiral twist. Long-curved flaments Similar structures are formed in certain liquid crystal phases.
None
Vascular senescence facilitates tissue repair
Dysfunctional senescent retinal vasculature produces senescence-associated secretory phenotype (SASP) components, attracts neutrophils, and stimulates the extrusion of neutrophil extracellular traps (NETosis, see photo below). This causes endothelial cell apoptosis and vascular pruning, which is essential for vascular repair and tissue recovery in ischemic retinopathy.
See this image and copyright information in PMC

Comment on

  • Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy.
    Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, Wilson AM, Buscarlet M, Mawambo GT, Howard JP, Diaz-Marin R, Parinot C, Guber V, Pilon F, Juneau R, Laflamme R, Sawchyn C, Boulay K, Leclerc S, Abu-Thuraia A, Côté JF, Andelfinger G, Rezende FA, Sennlaub F, Joyal JS, Mallette FA, Sapieha P. Binet F, et al. Science. 2020 Aug 21;369(6506):eaay5356. doi: 10.1126/science.aay5356. Science. 2020. PMID: 32820093

References

    1. Pries AR, Secomb TW, Physiol. 29, 446 (2014). - PMC - PubMed
    1. Watson EC, Grant ZL, Coultas L, Cell. Mol. Life Sci. 74, 4387 (2017). - PMC - PubMed
    1. Korn C, Augustin HG, Dev. Cell 34, 5 (2015). - PubMed
    1. Binet F et al., Science 369, eaay5356 (2020).
    1. Brinkmann V et al., Science 303, 1532 (2004). - PubMed

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