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Review
. 2020 Aug-Sep;36(8-9):753-762.
doi: 10.1051/medsci/2020130. Epub 2020 Aug 21.

[Macular edema: Understand mechanisms to develop treatments]

[Article in French]
Francine Behar-Cohen  1 , Min Zhao  2 , Emmanuelle Gelize  2 , Elodie Bousquet  3 , Alejandra Daruich  4 , Alexandre Matet  5 , Kimberley Delaunay  2 , Alicia Torriglia  2 , Marianne Berdugo-Polak  2 , Frédéric Jaisser, Yvonne de Kozak  2 , Patricia Lassiaz  2
Affiliations
Free article
Review

[Macular edema: Understand mechanisms to develop treatments]

[Article in French]
Francine Behar-Cohen et al. Med Sci (Paris). 2020 Aug-Sep.
Free article

Abstract
in English, French

Macular edema is an increase in volume of the central area of the retina, responsible for visual acuity. Visual symptoms handicap the lives of millions of patients with macular edema secondary to chronic and sometimes acute retinal disease. Proteins that neutralize the vascular endothelial growth factor (VEGF) pathway or glucocorticoids, at the cost of repeated intraocular injections over years, limit visual symptoms. A better understanding of why and how edema forms and how therapeutic molecules exert an anti-edematous effect will help prevent this disabling and blinding retinal complication from occurring.

Title: Les œdèmes maculaires - Mieux comprendre leurs mécanismes pour mieux les traiter.

Abstract: L’œdème maculaire est une augmentation de volume de la macula, zone centrale de la rétine, responsable de l’acuité visuelle. Des symptômes visuels handicapent la vie de millions de patients atteints d’œdème maculaire secondaire à une maladie chronique et parfois aiguë de la rétine. Les protéines qui neutralisent la voie du facteur de croissance de l’endothélium vasculaire (VEGF) ou les glucocorticoïdes, au prix d’injections intraoculaires répétées pendant des années, limitent les symptômes visuels. Mieux comprendre pourquoi et comment l’œdème se forme et comment les molécules thérapeutiques exercent un effet anti-œdémateux permettra de mieux prévenir la survenue de cette complication rétinienne handicapante et cécitante.

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References

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