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Review
. 2020 Aug 7:13:187-192.
doi: 10.2147/IJNRD.S236556. eCollection 2020.

BK Virus Nephropathy: Prevalence, Impact and Management Strategies

Rajeev Sharma  1   2 , Mareena Zachariah  3
Affiliations
Review

BK Virus Nephropathy: Prevalence, Impact and Management Strategies

Rajeev Sharma et al. Int J Nephrol Renovasc Dis. .

Abstract

BK virus reactivation as a result of therapeutic immunosuppression following renal transplant can result in BK polyomavirus nephropathy and renal allograft loss. This is a complex and challenging clinical problem with a range of management options and practices reported in literature. The current standard for early diagnosis and treatment is surveillance by measuring viral DNA in blood using qPCR. Immunosuppression reduction is the cornerstone of effective management but is associated with a risk of acute rejection following treatment.

Keywords: BK polyomavirus nephropathy; immune monitoring; kidney transplant; surveillance; treatment.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Monitoring and treatment protocol for BK viremia at our center.
See this image and copyright information in PMC

References

    1. Gardner SD, Field AM, Coleman DV, et al. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971;1(7712):1253–1257. doi:10.1016/S0140-6736(71)91776-4 - DOI - PubMed
    1. Chatterjee M, Weyandt TB, Frisque RJ. Identification of archetype and rearranged forms of BK virus in leukocytes from healthy individuals. J Med Virol. 2000;60(3):353–362. doi:10.1002/(SICI)1096-9071(200003)60:3<353::AID-JMV16>3.0.CO;2-R - DOI - PubMed
    1. Flaegstad T, Ronne K, Filipe AR, et al. Prevalence of anti BK virus antibody in Portugal and Norway. Scan J Infectious Dis. 1989;21(2):145–147. doi:10.3109/00365548909039961 - DOI - PubMed
    1. Stolt A, Sasnauskas K, Koskela P, et al. Seroepidemiology of the human polyomaviruses. J Gen Virol. 2003;84(Pt 6):1499–1504. doi:10.1099/vir.0.18842-0 - DOI - PubMed
    1. Goudsmit J, Wertheim-van Dillen P, van Strien A, et al. The role of BK virus in acute respiratory tract disease and the presence of BKV DNA in tonsils. J Med Virol. 1982;10(2):91–99. doi:10.1002/jmv.1890100203 - DOI - PubMed