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Case Reports
. 2020 Jun 19:36:106.
doi: 10.11604/pamj.2020.36.106.20577. eCollection 2020.

Congenital cytomegalovirus infection as an important cause of infantile cholestatic jaundice: a case report

Olufunmilola Olubisi Abolurin  1 , Idowu Odunayo Senbanjo  2 , Adesola Olubunmi Adekoya  1 , Emmanuel Damilare Ajibola  1
Affiliations
Case Reports

Congenital cytomegalovirus infection as an important cause of infantile cholestatic jaundice: a case report

Olufunmilola Olubisi Abolurin et al. Pan Afr Med J. .

Abstract

Infantile cholestasis has numerous causes and diagnosis can be difficult, especially in low-income countries where essential laboratory facilities are not readily available. This is a report of a baby who had severe conjugated neonatal hyperbilirubinaemia and deranged liver function tests, which posed a diagnostic dilemma before a diagnosis of congenital cytomegalovirus (CMV) infection was made. He was treated with Ganciclovir and responded well to treatment. He had no obvious associated neurologic manifestation of the disease and is presently been followed-up. This report highlights the challenges encountered in the diagnosis and management of the baby, as well as the favourable outcome with Ganciclovir therapy. The aim of the report is to increase the awareness of paediatricians and other stakeholders on congenital CMV infection in order to ensure early diagnosis and appropriate treatment of affected babies, with the ultimate aim of improving their prognoses and preventing the associated audiologic and cognitive sequelae.

Keywords: Congenital cytomegalovirus; cholestatic jaundice; ganciclovir; hepatitis; infant.

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Conflict of interest statement

The authors declare no competing interests.

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