Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun;199(6):2131-2137.
doi: 10.1007/s12011-020-02341-2. Epub 2020 Aug 21.

The Joint Role of Iodine Status and Thyroid Function on Risk for Preeclampsia in Finnish Women: a Population-Based Nested Case-Control Study

Elijah C Reische  1 , Tuija Männistö  2 , Alexandra Purdue-Smithe  1 , Kurunthachalam Kannan  3 , Un-Jung Kim  4 , Eila Suvanto  2 , Heljä-Marja Surcel  5   6 , Mika Gissler  7   8 , James L Mills  9
Affiliations

The Joint Role of Iodine Status and Thyroid Function on Risk for Preeclampsia in Finnish Women: a Population-Based Nested Case-Control Study

Elijah C Reische et al. Biol Trace Elem Res. 2021 Jun.

Abstract

Preeclampsia, a pregnancy disorder that includes hypertension and proteinuria, is a major cause of maternal and fetal morbidity and mortality. Some studies, but not all, have found that women with preeclampsia have significantly lower iodine levels than healthy pregnant women. Resolving this issue is important because iodine deficiency in pregnancy is common in the USA and parts of Europe including Finland. We conducted a nested case-control study to determine whether the risk for preeclampsia is associated with iodine status. We measured serum iodine, thyroglobulin (Tg), and thyroid stimulating hormone (TSH) at 10-14 weeks gestational age in 204 women with preeclampsia and 246 unaffected controls selected from all births in Finland. We found no significant difference in iodine (case mean = 26.04 ng/mL, control mean = 27.88 ng/mL, p = 0.995), Tg (case mean = 31.11 ng/mL, control mean = 29.61 ng/mL, p = 0.996), and TSH (case mean = 1.30 mIU/L, control mean = 1.24 mIU/L, p = 0.896) levels between cases and controls. There was no significant relationship between preeclampsia risk and iodine, Tg, or TSH after adjustment for known risk factors. These results are reassuring given the high prevalence of iodine deficiency in pregnancy.

Keywords: Iodine; Preeclampsia; Pregnancy; Thyroglobulin; Thyroid hormones; Thyroid stimulating hormone.

PubMed Disclaimer

References

    1. The American College of Obstetricians and Gynecologists (2019) ACOG practice bulletin number 202: gestational hypertension and preeclampsia. Obstet Gynecol 133(1):e1–e325
    1. Hutcheon JA, Lisonkova S, Joseph KS (2011) Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Rev Best Pract Res Clin Obstet Gynaecol 25(4):391–403. https://doi.org/10.1016/j.bpobgyn.2011.01.006 - DOI
    1. Burton GJ, Redman CW, Roberts JM, Moffett A (2019) Pre-eclampsia: pathophysiology and clinical implications. BMJ 366:l2381. https://doi.org/10.1136/bmj.l2381 - DOI - PubMed
    1. Young BC, Levine RJ, Karumanchi SA (2010) Pathogenesis of preeclampsia. Rev Annu Rev Pathol 5:173–192. https://doi.org/10.1146/annurev-pathol-121808-102149 - DOI - PubMed
    1. Cuellar-Rufino S, Navarro-Meza M, García-Solís P, Xochihua-Rosas I, Arroyo-Helguera O (2017) Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease. Nutr Hosp 34(3):661–666. https://doi.org/10.20960/nh.460 - DOI - PubMed

LinkOut - more resources