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. 2020 Sep;35(9):1495-1496.
doi: 10.1002/mds.28231. Epub 2020 Aug 21.

Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease

Cristian Follmer  1
Affiliations

Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease

Cristian Follmer. Mov Disord. 2020 Sep.
No abstract available

Keywords: Parkinson's disease; coronavirus; microbiome; neuroinflammation; α-synuclein.

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Figures

FIG. 1
FIG. 1
Viral infection‐induced gut microbiome imbalance, neuroinflammation and aSyn aggregation. Viral infection might promote gut dysbiosis and intestinal inflammation, which can lead to impaired mucosal integrity and release of LPS that, in turn, might stimulate the formation of deposits of aSyn in enteric nerves and neuroinflammation via microglial activation. Viral infection may also induce an increase in aSyn expression in enteric neurons as part of the immune response to the infection, contributing to the formation of aSyn aggregates that eventually may migrate from the intestine to the brain via the vagal nerve. This figure was created using Servier Medical Art templates, which are licensed under a Creative Commons Attribution 3.0 Unported License; https://smart.servier.com. [Color figure can be viewed at wileyonlinelibrary.com]
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