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Review
. 1977:7:1-46.
doi: 10.1007/978-1-4684-3054-7_1.

Two main features of T-cell development: thymus traffic and postthymic maturation

Review

Two main features of T-cell development: thymus traffic and postthymic maturation

O Stutman. Contemp Top Immunobiol. 1977.

Abstract

It appears from the results presented in Table V and discussed in the preceding pages that a precursor population of immunologically competent T cells can be characterized and defined by multiple biological criteria as being probably of postthymic origin and substantially different from either the immunologically competent T lymphocyte or the prethymic stem cells. On the basis of recent data on functional characteristics of of different subsets of T cells, which suggest parallel lines of differentiation (see Chapter 2), it is possibile that the postthymic precursor compartment may also show heterogeneity; however, this cannot be presently asserted from our results.

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