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Comment
. 2020 Aug 20;79(4):544-545.
doi: 10.1016/j.molcel.2020.07.029.

Partitioning of Chemotherapeutics into Nuclear Condensates-Opening the Door to New Approaches for Drug Development

Thomas P Howard  1 , Charles W M Roberts  2
Affiliations
Free article
Comment

Partitioning of Chemotherapeutics into Nuclear Condensates-Opening the Door to New Approaches for Drug Development

Thomas P Howard et al. Mol Cell. .
Free article

Abstract

Klein et al. (2020) demonstrate for the first time that small-molecule cancer therapeutics are selectively partitioned and concentrated within phase-separated nuclear condensates, providing new insights to drug efficacy and creating the opportunity for enhanced control of therapeutic targeting.

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  • Partitioning of cancer therapeutics in nuclear condensates.
    Klein IA, Boija A, Afeyan LK, Hawken SW, Fan M, Dall'Agnese A, Oksuz O, Henninger JE, Shrinivas K, Sabari BR, Sagi I, Clark VE, Platt JM, Kar M, McCall PM, Zamudio AV, Manteiga JC, Coffey EL, Li CH, Hannett NM, Guo YE, Decker TM, Lee TI, Zhang T, Weng JK, Taatjes DJ, Chakraborty A, Sharp PA, Chang YT, Hyman AA, Gray NS, Young RA. Klein IA, et al. Science. 2020 Jun 19;368(6497):1386-1392. doi: 10.1126/science.aaz4427. Science. 2020. PMID: 32554597 Free PMC article.

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