CSF1R Inhibitor Prevents Glioblastoma Recurrence
- PMID: 32826234
- DOI: 10.1158/2159-8290.CD-NB2020-078
CSF1R Inhibitor Prevents Glioblastoma Recurrence
Abstract
A mouse study suggests that daily doses of a CSF1R inhibitor after radiation therapy can reduce the likelihood of glioblastoma recurrence. Mice that received the inhibitor lived more than twice as long as control animals, and only 20% of them developed recurrent tumors, whereas all control animals did.
©2020 American Association for Cancer Research.
Comment on
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Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance.Sci Transl Med. 2020 Jul 15;12(552):eaaw7843. doi: 10.1126/scitranslmed.aaw7843. Sci Transl Med. 2020. PMID: 32669424
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