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. 2021 Jan;53(1):26-37.
doi: 10.1249/MSS.0000000000002454.

Novel CPET Reference Values in Healthy Adults: Associations with Physical Activity

Jonathan Wagner  1 , Raphael Knaier  1 , Denis Infanger  1 , Karsten Königstein  1 , Christopher Klenk  1 , Justin Carrard  1 , Henner Hanssen  1 , Timo Hinrichs  1 , Douglas Seals  2 , Arno Schmidt-Trucksäss  1
Affiliations

Novel CPET Reference Values in Healthy Adults: Associations with Physical Activity

Jonathan Wagner et al. Med Sci Sports Exerc. 2021 Jan.

Abstract

Purpose: Cardiopulmonary exercise testing (CPET) is an important measurement in clinical practice, and its primary outcome, maximal oxygen uptake (V˙O2peak), is inversely associated with morbidity and mortality. The purposes of this study are to provide CPET reference values for maximal and submaximal parameters across the adult age spectrum of a healthy European cohort, to compare V˙O2peak values with other reference data sets, and to analyze the associations between physical activity (PA) levels and CPET parameters.

Methods: In this cross-sectional study, we prospectively recruited 502 participants (47% female) from 20 to 90 yr old. The subjects performed a CPET on a cycle ergometer using a ramp protocol. PA was objectively and continuously measured over 14 d using a triaxial accelerometer. Quantile curves were calculated for CPET parameters. To investigate the associations between CPET parameters and PA levels, linear regression analysis was performed.

Results: V˙O2peak values observed in the group of 20-29 yr were 46.6 ± 7.9 and 39.3 ± 6.5 mL·kg⋅min for males and females, respectively. On average, each age category (10-yr increments) showed a 10% lower V˙O2peak relative to the next younger age category. V˙O2peak values of previous studies were on average 7.5 mL·kg⋅min (20%) lower for males and 6.5 mL·kg⋅min (21%) lower for females. There was strong evidence supporting a positive association between the V˙O2peak (mL·kg⋅min) and the level of habitual PA performed at vigorous PA (estimate, 0.26; P < 0.001].

Conclusion: Maximal and submaximal CPET reference values over a large age range are novel, and differences to other studies are clinically highly relevant. Objectively measured vigorous-intensity PA showed a strong positive association with higher V˙O2peak and other performance-related CPET parameters, supporting the implementation of higher-intensity aerobic exercise in health promotion.

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