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. 2020 Nov;36(11):813-815.
doi: 10.1016/j.tig.2020.08.003. Epub 2020 Aug 10.

Host Polymorphisms May Impact SARS-CoV-2 Infectivity

Patrick Brest  1 , Sadal Refae  2 , Baharia Mograbi  1 , Paul Hofman  3 , Gerard Milano  4
Affiliations

Host Polymorphisms May Impact SARS-CoV-2 Infectivity

Patrick Brest et al. Trends Genet. 2020 Nov.

Abstract

Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.

Keywords: SNP; coronavirus; genetic variation; infection; pharmacogenetics.

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Figures

Figure 1
Figure 1
Graphic Support for the Hypothesis of Angiotensin-Converting Enzyme 2 (ACE2)-Related Virus Neutralization at Distance due to the Presence of Enzymatic Membrane Mechanisms Regulating ACE2 Shedding and Virus Entry. Abbreviations: ADAM17, disintegrin and metalloproteinase domain-containing protein 17; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TMPRSS2, transmembrane protease serine 2.
See this image and copyright information in PMC

References

    1. Xie C. Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests. Int. J. Infect. Dis. 2020;93:264–267. - PMC - PubMed
    1. Casanova J.-L. A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection. Cell. 2020;181:1194–1199. - PMC - PubMed
    1. Chen J. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell. 2020;19 - PMC - PubMed
    1. Heurich A. TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J. Virol. 2014;88:1293–1307. - PMC - PubMed
    1. Cao Y. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell Discov. 2020;6:4–7. - PMC - PubMed

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