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. 2021 Apr;41(4):836-842.
doi: 10.1038/s41372-020-00794-w. Epub 2020 Aug 22.

Changes in cerebral tissue oxygenation and fractional oxygen extraction with gestational age and postnatal maturation in preterm infants

Mohamed A Mohamed  1 , Michael J Frasketi  2 , Safwat Aly  3 , Mohamed El-Dib  4 , Heather J Hoffman  2 , Hany Aly  5
Affiliations

Changes in cerebral tissue oxygenation and fractional oxygen extraction with gestational age and postnatal maturation in preterm infants

Mohamed A Mohamed et al. J Perinatol. 2021 Apr.

Abstract

Objective: This study examined the correlation of cerebral tissue oxygen saturation (SctO2) and cerebral tissue fractional oxygen extraction (cFTOE) with gestational age (GA) and postnatal age over the first 28 days of life.

Study design: Preterm infants with birth weight (BW) <1500 g were monitored with near-infrared spectroscopy (NIRS) during the first 28 days of life. SctO2 and cFTOE measurements were analyzed using a linear mixed model.

Results: A total of 70 preterm infants were included. Mean SctO2 decreased with increasing GA; SctO2 was 76.4% and 74.6% in the first 24 h for infants 24 and 28-week GA, respectively. For infants born at 24 and 28 it decreased to 52.9% and 58.4% at 28 days of life, respectively. cFTOE increased with increasing GA and postnatal age.

Conclusions: There is an inverse relationship between SctO2 and gestational age and postnatal age but a direct relationship between cFTOE with GA and postnatal age.

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References

    1. Janvier A, Khairy M, Kokkotis A, Cormier C, Messmer D, Barrington KJ. Apnea is associated with neurodevelopmental impairment in very low birth weight infants. J Perinatol. 2004;24:763–8. - DOI
    1. Martin RJ, Wang K, Koroglu O, Di Fiore JM, Kc P. Intermittent hypoxic episodes in preterm infants: Do they matter? Neonatology. 2011;100:303–10. - DOI
    1. Wolfberg AJ, du Plessis AJ. Near-infrared spectroscopy in the fetus and neonate. Clin Perinatol. 2006;33:707–28. - DOI
    1. Wolf M, Greisen G. Advances in near-infrared spectroscopy to study the brain of the preterm and term neonate. Clin Perinatol. 2009;36:807–34. - DOI
    1. Wyatt JS, Edwards AD, Cope M, Delpy DT, McCormick DC, Potter A, et al. Response of cerebral blood volume to changes in arterial carbon dioxide tension in preterm and term infants. Pediatr Res. 1991;29:553–7. - DOI

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