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. 2019 Aug:10:96-101.
doi: 10.1016/j.cophys.2019.05.005. Epub 2019 May 9.

Precision remodeling: how exercise improves mitochondrial quality in myofibers

Joshua C Drake  1 , Zhen Yan  1   2   3   4
Affiliations

Precision remodeling: how exercise improves mitochondrial quality in myofibers

Joshua C Drake et al. Curr Opin Physiol. 2019 Aug.

Abstract

The profound energetic demand of prolonged exercise imposed upon skeletal muscle and the heart is met by oxidation of substrate within mitochondria. As such, several coordinated events are initiated in order to maintain mitochondria, collectively known as mitochondrial quality control. In this review, we discuss how mitochondrial quality control functions to maintain the integrity of the reticulum and energy production in response to prolonged exercise, as well as the relevant signaling events that dictate these responses. Based upon the prevailing data in the field, we propose a model where exercise-mediated quality control may be chiefly regulated through local mechanisms, thus allowing for the remarkable precision in mitochondrial quality control events.

Keywords: exercise; mitochondria; mitophagy; muscle; myofiber; quality control.

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Conflict of interest statement

Competing Financial Interests The authors declare no competing financial interests

Figures

Figure 1.
Figure 1.
Model for domain-specific regulation of mitochondria quality control. A) Representative image of exercise-induced mitophagy in skeletal muscle (Laker and Drake, et al. Nat Commun. 2017, 8: 548). B) Quantification of mitochondria engulfed in autolysosomes (red puncta) relative to total mitochondrial area. Based on data published in Laker and Drake, et al. Nat Commun. 2017, 8: 548. While semi-quantitative, this calculation illustrates that the areas of the reticulum targeted for mitophagy in response to acute exercise is a small fraction of the network. C) Illustration of local-mediation of mitochondria quality control to maintain energetic homeostasis and adaptation to energetic stress.
See this image and copyright information in PMC

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