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. 2021 Jun 1;113(6):792-796.
doi: 10.1093/jnci/djaa128.

Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017

Ashish A Deshmukh  1 , Ryan Suk  1 , Meredith S Shiels  2 , Haluk Damgacioglu  1 , Yueh-Yun Lin  1 , Elizabeth A Stier  3 , Alan G Nyitray  4 , Elizabeth Y Chiao  5 , Gizem S Nemutlu  6 , Jagpreet Chhatwal  6 , Kathleen Schmeler  7 , Keith Sigel  8   9 , Kalyani Sonawane  1   10
Affiliations

Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017

Ashish A Deshmukh et al. J Natl Cancer Inst. .

Abstract

Human papillomavirus (HPV)-associated anal and oropharyngeal cancer incidence has increased in recent years among US women. However, trends in incidence and burden (annual number of cases) of noncervical HPV-associated cancers relative to cervical cancer remain unclear. Using the 2001-2017 US cancer statistics dataset, we evaluated contemporary incidence trends and burden (annual number of cases) of HPV-associated cancers among women by anatomic site, race or ethnicity, and age. Overall, cervical cancer incidence plateaued among White women but continued to decline among Black and Hispanic women. Anal cancer incidence surpassed cervical cancer incidence among White women aged 65-74 years of age (8.6 and 8.2 per 100 000 in 2015) and 75 years or older (6.2 and 6.0 per 100 000 in 2014). The noncervical cancer burden (n = 11 871) surpassed the cervical cancer burden (n = 11 527) in 2013. Development of efficacious screening strategies for noncervical cancers and continued improvement in cervical cancer prevention are needed to combat HPV-associated cancers among women.

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Figures

Figure 1.
Figure 1.
Trends in the annual incidence rates of cervical, anal, vulvar, vaginal, and oropharyngeal cancers among women according to age at diagnosis and race/ethnicity: National Program of Cancer Registries and Surveillance Epidemiology, and End Results program (2001-2017). Data markers represent the observed incidence rates (cases per 100 000 person-years). Panels A, B, C, and D show cervical, anal, vulvar, vaginal, and oropharyngeal cancer incidence trends among White women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Panels E, F, G, and H show cervical, anal, vulvar, vaginal, and oropharyngeal cancer incidence trends among Black women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Panels I, J, K, and L show cervical, anal, vulvar, vaginal, and oropharyngeal cancer incidence trends among Hispanic women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Rates are age-adjusted to the 2000 US standard population. NH = non-Hispanic. *P < .05.
Figure 2.
Figure 2.
Burden (annual number of cases) of cervical, anal, vulvar, vaginal, and oropharyngeal cancers among women according to age at diagnosis at race or ethnicity: National Program of Cancer Registries and Surveillance Epidemiology, and End Results program (2001-2017). Vertical bars represent the burden (annual number of cases). Panels A, B, C, and D show cervical, anal, vulvar, vaginal, and oropharyngeal cancer burden among White women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Panels E, F, G, and H show cervical, anal, vulvar, vaginal, and oropharyngeal cancer burden among Black women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Panels I, J, K, and L show cervical, anal, vulvar, vaginal, and oropharyngeal cancer incidence burden among Hispanic women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. HPV = human papillomavirus; NH = non-Hispanic.
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