Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun 1;113(6):792-796.
doi: 10.1093/jnci/djaa128.

Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017

Ashish A Deshmukh  1 , Ryan Suk  1 , Meredith S Shiels  2 , Haluk Damgacioglu  1 , Yueh-Yun Lin  1 , Elizabeth A Stier  3 , Alan G Nyitray  4 , Elizabeth Y Chiao  5 , Gizem S Nemutlu  6 , Jagpreet Chhatwal  6 , Kathleen Schmeler  7 , Keith Sigel  8   9 , Kalyani Sonawane  1   10
Affiliations

Incidence Trends and Burden of Human Papillomavirus-Associated Cancers Among Women in the United States, 2001-2017

Ashish A Deshmukh et al. J Natl Cancer Inst. .

Abstract

Human papillomavirus (HPV)-associated anal and oropharyngeal cancer incidence has increased in recent years among US women. However, trends in incidence and burden (annual number of cases) of noncervical HPV-associated cancers relative to cervical cancer remain unclear. Using the 2001-2017 US cancer statistics dataset, we evaluated contemporary incidence trends and burden (annual number of cases) of HPV-associated cancers among women by anatomic site, race or ethnicity, and age. Overall, cervical cancer incidence plateaued among White women but continued to decline among Black and Hispanic women. Anal cancer incidence surpassed cervical cancer incidence among White women aged 65-74 years of age (8.6 and 8.2 per 100 000 in 2015) and 75 years or older (6.2 and 6.0 per 100 000 in 2014). The noncervical cancer burden (n = 11 871) surpassed the cervical cancer burden (n = 11 527) in 2013. Development of efficacious screening strategies for noncervical cancers and continued improvement in cervical cancer prevention are needed to combat HPV-associated cancers among women.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Trends in the annual incidence rates of cervical, anal, vulvar, vaginal, and oropharyngeal cancers among women according to age at diagnosis and race/ethnicity: National Program of Cancer Registries and Surveillance Epidemiology, and End Results program (2001-2017). Data markers represent the observed incidence rates (cases per 100 000 person-years). Panels A, B, C, and D show cervical, anal, vulvar, vaginal, and oropharyngeal cancer incidence trends among White women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Panels E, F, G, and H show cervical, anal, vulvar, vaginal, and oropharyngeal cancer incidence trends among Black women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Panels I, J, K, and L show cervical, anal, vulvar, vaginal, and oropharyngeal cancer incidence trends among Hispanic women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Rates are age-adjusted to the 2000 US standard population. NH = non-Hispanic. *P < .05.
Figure 2.
Figure 2.
Burden (annual number of cases) of cervical, anal, vulvar, vaginal, and oropharyngeal cancers among women according to age at diagnosis at race or ethnicity: National Program of Cancer Registries and Surveillance Epidemiology, and End Results program (2001-2017). Vertical bars represent the burden (annual number of cases). Panels A, B, C, and D show cervical, anal, vulvar, vaginal, and oropharyngeal cancer burden among White women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Panels E, F, G, and H show cervical, anal, vulvar, vaginal, and oropharyngeal cancer burden among Black women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. Panels I, J, K, and L show cervical, anal, vulvar, vaginal, and oropharyngeal cancer incidence burden among Hispanic women younger than 50 years, aged 50-64 years, 65-74 years, and 75 years and older, respectively. HPV = human papillomavirus; NH = non-Hispanic.
See this image and copyright information in PMC

References

    1. Islami F, Fedewa SA, Jemal A. Trends in cervical cancer incidence rates by age, race/ethnicity, histological subtype, and stage at diagnosis in the United States. Prev Med. 2019;123:316–323. - PubMed
    1. Deshmukh AA, Suk R, Shiels MS, et al. Recent trends in squamous cell carcinoma of the anus incidence and mortality in the United States, 2001-2015. J Natl Cancer Inst. 2020;112(8):829–838. - PMC - PubMed
    1. Tota JE, Best AF, Zumsteg ZS, et al. Evolution of the oropharynx cancer epidemic in the United States: moderation of increasing incidence in younger individuals and shift in the burden to older individuals. J Clin Oncol. 2019;37(18):1538–1546. - PMC - PubMed
    1. National Program of Cancer Registries and Surveillance, Epidemiology, and End Results SEER*Stat Database: NPCR and SEER Incidence – U.S. Cancer Statistics 2001–2017 Public Use Research Database, 2019 submission (2001–2017), United States Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute. Published June 2020. www.cdc.gov/cancer/uscs/public-use. Accessed July 31, 2020.
    1. Van Dyne EA, Henley SJ, Saraiya M, et al. Trends in human papillomavirus-associated cancers—United States, 1999-2015. MMWR Morb Mortal Wkly Rep. 2018;67(33):918–924. - PMC - PubMed

Publication types