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. 2020;54(3):241-257.
doi: 10.1007/s11094-020-02187-x. Epub 2020 Jun 15.

Current Strategies in Development of New Chromone Derivatives with Diversified Pharmacological Activities: A Review

Noor Ul Amin Mohsin  1 , Muhammad Irfan  2 , Shams Ul Hassan  2 , Usman Saleem  2
Affiliations

Current Strategies in Development of New Chromone Derivatives with Diversified Pharmacological Activities: A Review

Noor Ul Amin Mohsin et al. Pharm Chem J. 2020.

Abstract

Chromone derivatives possess a spectrum of biological activities. Chromone has been recognized as a privileged structure for new drug invention and development. Substitution pattern of chromone scaffold determines different type of biological activities. The type, number and position of substituents connected to the chromone core play a vital role in determining pharmacological activities. In the present review, we have discussed new chromone derivatives as anticancer, anti-diabetic, antimicrobial, anti-inflammatory, antioxidant and as anti-Alzheimer agents. This review deals with the chromone derivatives prepared by combining chromone molecule with various natural and synthetic pharmacophores and pharmacological activities presented by them. The main aim is to highlight the diversified pharmacological activities exhibited by chromone hybrid molecules during the last eight to ten years.

Keywords: anti-Alzheimer; anti-inflammatory; anticancer; antimicrobial; antioxidant, anti-diabetic; chromones.

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Figures

Fig. 1
Fig. 1
Structural formulas of (1) chromone and (2) 3-formyl chromone.
Fig. 2
Fig. 2
Chromone derived molecules 3 – 9 as anticancer agents.
Fig. 3
Fig. 3
Chromone derivatives 10 – 20 as anticancer agents.
Fig. 4
Fig. 4
Chromone derivatives 21 – 29 as anticancer agents.
Fig. 5
Fig. 5
Chromone derivatives 30 – 37 as antidiabetic agents.
Fig. 6
Fig. 6
Chromone derivatives 38 – 45 as antimicrobial agents.
Fig. 7
Fig. 7
Chromone derivatives 46 – 64 as antimicrobial agents.
Fig. 8
Fig. 8
Chromones 65 – 81 as antimicrobial agents.
Fig. 9
Fig. 9
Chromone derivatives 82 – 90 as antimicrobial agents.
Fig. 10
Fig. 10
Chromone derivatives 93 – 97 as anti-inflammatory agents.
Fig. 11
Fig. 11
Chromone derived molecules 98 – 107 as anti-Alzheimer agents.
Fig. 12
Fig. 12
Chromone derivatives 108 – 117 as antioxidant agents.
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