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Editorial
. 2020 May 23:101232.
doi: 10.1016/j.ppedcard.2020.101232. Online ahead of print.

COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; a Western New York approach

Teresa R Hennon  1   2 , Michelle D Penque  1   2 , Rabheh Abdul-Aziz  1   2 , Omar S Alibrahim  1   2 , Megan B McGreevy  1   2 , Andrew J Prout  1   2 , Beverly A Schaefer  1   2 , Steven J Ambrusko  1   2 , John V Pastore  1   2 , Stephen J Turkovich  1   2 , Oscar G Gomez-Duarte  1   2 , Mark D Hicar  1   2
Affiliations
Editorial

COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; a Western New York approach

Teresa R Hennon et al. Prog Pediatr Cardiol. .
No abstract available

Keywords: ASO, antistreptolysin O; BNP, brain-natriuretic peptide; CBC, complete blood count; CDC, Center for Disease Control; COVID-19; COVID-19, severe viral respiratory infection caused by SARS-CoV-2; CRP, C-reactive protein; CSS, cytokine storm syndrome; ECMO, extracorporeal membrane oxygenation; Fever; GI, gastrointestinal; HLH, hemophagocytic lymphohistiocytosis; ICU, intensive care unit; IVIG, intravenous immunoglobulin; Inflammation; KD, Kawasaki disease; LDH, lactate dehydrogenase; LFTs, liver function tests; MAS, macrophage activation syndrome; MIS-C; MIS-C, Multisystem Inflammatory Syndrome in Children; PCAID, Pediatric COVID-19 Associated Inflammatory Disorder; PMIS, Pediatric Multisystem Inflammatory Syndrome; PT, prothrombin Time; PTT, partial Thromboplastin Time; Pediatric; SARS-CoV-2; TNF, tumor necrosis factor; VA, veno-arterial; VTE, venous thromboembolic events.

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Conflict of interest statement

Authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Proposed guidelines for evaluation of a child with suspected MIS-C. Guideline was created following the CDC case definition with input from emergency medicine physicians, hospitalists, intensivists, and specialists in the areas of infectious diseases, cardiology, rheumatology, and hematology.
See this image and copyright information in PMC

References

    1. Qiu H., Wu J., Hong L. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020 Mar 25 doi: 10.1016/S1473-3099(20)30198-5. S1473-3099(20)30198-5, ahead of print. - DOI - PMC - PubMed
    1. DeBiasi R.L., Song X., Delaney M. Severe COVID-19 in children and young adults in the Washington, DC Metropolitan Region. J Pediatr. 2020 doi: 10.1016/j.jpeds.2020.05.007. in press. - DOI - PMC - PubMed
    1. Verdoni L., Mazza A., Gervasoni A. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020 doi: 10.1016/S0140-6736(20)31103-X. ahead of print. - DOI - PMC - PubMed
    1. Riphagen S., Gomez X., Gonzalez-Martinez C., Wilkinson N., Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020 May 7 doi: 10.1016/S0140-6736(20)31094-1. S0140-6736(20)31094-1, ahead of print. - DOI - PMC - PubMed
    1. Belhadjer Z., Meot M., Bajolle F. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020 May 17 doi: 10.1161/CIRCULATIONAHA.120.048360. ahead of print. - DOI - PubMed

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