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. 2020 Oct;6(10):1073-1075.
doi: 10.1016/j.eng.2020.05.015. Epub 2020 Jun 10.

Mesenchymal Stem Cells Represent a Potential Therapeutic Option for Coronavirus Disease 2019-Related Acute Respiratory Distress Syndrome

Xuan Zhao  1 , Yi Zhang  1
Affiliations

Mesenchymal Stem Cells Represent a Potential Therapeutic Option for Coronavirus Disease 2019-Related Acute Respiratory Distress Syndrome

Xuan Zhao et al. Engineering (Beijing). 2020 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1
Potential mechanisms involved in MSC therapy for ARDS. MSCs exert therapeutic effects for the treatment of ARDS through different mechanisms. MSCs can secrete a number of factors including IL-10, IL-1 receptor antagonist (Ra), fibroblast growth factor 7 (FGF7), insulin-like growth factor 1 (IGF-1), VEGF, and TGF-β1, reduce the production of pro-inflammatory cytokines including IL-6, tumor necrosis factor (TNF)-α, and IFN-γ, and improve the activity of macrophages. Once recruited and/or entrapped in the local microcirculation and/or pulmonary vasculature, activating factors released from local cells (both endothelium and locally recruited inflammatory cells) are able to stimulate MSCs to release various paracrine mediators, enhancing their ability to regenerate and repair damaged lung tissue. M2 macrophage: alternatively activated macrophage.
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