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. 1977 Jun;32(6):893-8.

Presence and production of migration inhibitory activity in the peritoneal cavity

A C Van Maarsseveen

Presence and production of migration inhibitory activity in the peritoneal cavity

A C Van Maarsseveen. Immunology. 1977 Jun.

Abstract

The presence of migration inhibitory (MI) activity was investigated in the delayed hypersensitivity (DH) reaction induced by i.p. injection of PPD into FCA-sensitized guinea-pigs. Peritoneal exudates were studied at several times before and after the induction of the DH reaction and a non-immune control inflammation. Lymphokine (LK) fractions were prepared from individual exudates and tested in a conventional macrophage migration inhibition assay at concentrations determined to occur in vivo. The results suggest a continuous local production of MI activity and an augmented production during development of a DH reaction.

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