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Meta-Analysis
. 2020 Aug 24;10(1):14136.
doi: 10.1038/s41598-020-71104-9.

Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis

Hyun Min Koh  1 , Bo Gun Jang  2   3 , Dong Chul Kim  4   5   6
Affiliations
Meta-Analysis

Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis

Hyun Min Koh et al. Sci Rep. .

Abstract

Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic significance of Rab27 expression in solid cancer. Data were extracted by searching on PubMed, Embase and Cochrane library until February 15 2020. Pooled hazard ratio (HR) with confidence interval (CI) was calculated to evaluate the association between Rab27 expression and survival in solid cancer. Ten studies with 1434 cancer patients were including for this meta-analysis. High expression of Rab27 was associated with poor survival (HR 2.67, 95% CI 1.52-4.69, p = 0.001). High expression of Rab27A was significantly associated with lymph node metastasis (HR 1.53, 95% CI 1.00-2.34, p = 0.048). High expression of Rab27B was significantly correlated with lymph node and distant metastasis (HR 2.15, 95% CI 1.56-2.95, p < 0.001; HR 6.80, 95% CI 3.12-14.85, p < 0.001), and higher TNM stage (HR 2.55, 95% CI 1.78-3.65, p < 0.001). This meta-analysis revealed that Rab27 expression could be a potential prognostic marker in solid cancer.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of study selection.
Figure 2
Figure 2
Forest plot of the association between Rab27 expression and survival.
Figure 3
Figure 3
Forest plot for survival stratified by cancer type (A), sample size (B) survival outcome (C), and protein type (D).
Figure 3
Figure 3
Forest plot for survival stratified by cancer type (A), sample size (B) survival outcome (C), and protein type (D).
Figure 4
Figure 4
Forest plot of the association between Rab27A expression and clinicopathological characteristics. (A) lymph node metastasis, (B) age, (C) gender, (D) tumor grade, (E) tumor stage, (F) distant metastasis, (G) TNM stage.
Figure 4
Figure 4
Forest plot of the association between Rab27A expression and clinicopathological characteristics. (A) lymph node metastasis, (B) age, (C) gender, (D) tumor grade, (E) tumor stage, (F) distant metastasis, (G) TNM stage.
Figure 4
Figure 4
Forest plot of the association between Rab27A expression and clinicopathological characteristics. (A) lymph node metastasis, (B) age, (C) gender, (D) tumor grade, (E) tumor stage, (F) distant metastasis, (G) TNM stage.
Figure 5
Figure 5
Forest plot of the association between Rab27B expression and clinicopathological characteristics. (A) lymph node metastasis, (B) distant metastasis, (C) TNM stage, (D) age, (E) gender, (F) tumor size, (G) tumor grade, (H) tumor stage.
Figure 5
Figure 5
Forest plot of the association between Rab27B expression and clinicopathological characteristics. (A) lymph node metastasis, (B) distant metastasis, (C) TNM stage, (D) age, (E) gender, (F) tumor size, (G) tumor grade, (H) tumor stage.
Figure 5
Figure 5
Forest plot of the association between Rab27B expression and clinicopathological characteristics. (A) lymph node metastasis, (B) distant metastasis, (C) TNM stage, (D) age, (E) gender, (F) tumor size, (G) tumor grade, (H) tumor stage.
Figure 6
Figure 6
Funnel plot (A) and trim and fill method (B) of the association between Rab27 expression and survival.
Figure 7
Figure 7
Sensitivity analysis of the association between Rab27 expression and survival.
See this image and copyright information in PMC

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