The road ahead in genetics and genomics

Amy L McGuire¹, Stacey Gabriel², Sarah A Tishkoff^{3

4}, Ambroise Wonkam^{5

6}, Aravinda Chakravarti⁷, Eileen E M Furlong⁸, Barbara Treutlein⁹, Alexander Meissner^{10

11

12

13}, Howard Y Chang¹⁴, Núria López-Bigas^{15

16

17}, Eran Segal¹⁸, Jin-Soo Kim¹⁹

Affiliations

¹ Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA. amcguire@bcm.edu.
² Broad Institute of MIT and Harvard, Cambridge, MA, USA. stacey@broadinstitute.org.
³ Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA. tishkoff@pennmedicine.upenn.edu.
⁴ Department of Biology, University of Pennsylvania, Philadelphia, PA, USA. tishkoff@pennmedicine.upenn.edu.
⁵ Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. ambroise.wonkam@uct.ac.za.
⁶ Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. ambroise.wonkam@uct.ac.za.
⁷ Center for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY, USA. aravinda.chakravarti@nyulangone.org.
⁸ European Molecular Biology Laboratory, Genome Biology Department, Heidelberg, Germany. furlong@embl.de.
⁹ Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. barbara.treutlein@bsse.ethz.ch.
¹⁰ Broad Institute of MIT and Harvard, Cambridge, MA, USA. meissner@molgen.mpg.de.
¹¹ Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany. meissner@molgen.mpg.de.
¹² Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. meissner@molgen.mpg.de.
¹³ Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. meissner@molgen.mpg.de.
¹⁴ Center for Personal Dynamic Regulomes, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. howchang@stanford.edu.
¹⁵ Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. nuria.lopez@irbbarcelona.org.
¹⁶ Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain. nuria.lopez@irbbarcelona.org.
¹⁷ Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain. nuria.lopez@irbbarcelona.org.
¹⁸ Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel. eran.segal@weizmann.ac.il.
¹⁹ Center for Genome Engineering, Institute for Basic Science, Daejon, Republic of Korea. jskim01@snu.ac.kr.

PMID: 32839576
PMCID: PMC7444682
DOI: 10.1038/s41576-020-0272-6

Review

The road ahead in genetics and genomics

Amy L McGuire et al. Nat Rev Genet. 2020 Oct.

. 2020 Oct;21(10):581-596.

doi: 10.1038/s41576-020-0272-6. Epub 2020 Aug 24.

Authors

Affiliations

¹ Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA. amcguire@bcm.edu.
² Broad Institute of MIT and Harvard, Cambridge, MA, USA. stacey@broadinstitute.org.
³ Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA. tishkoff@pennmedicine.upenn.edu.
⁴ Department of Biology, University of Pennsylvania, Philadelphia, PA, USA. tishkoff@pennmedicine.upenn.edu.
⁵ Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. ambroise.wonkam@uct.ac.za.
⁶ Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. ambroise.wonkam@uct.ac.za.
⁷ Center for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY, USA. aravinda.chakravarti@nyulangone.org.
⁸ European Molecular Biology Laboratory, Genome Biology Department, Heidelberg, Germany. furlong@embl.de.
⁹ Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland. barbara.treutlein@bsse.ethz.ch.
¹⁰ Broad Institute of MIT and Harvard, Cambridge, MA, USA. meissner@molgen.mpg.de.
¹¹ Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany. meissner@molgen.mpg.de.
¹² Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. meissner@molgen.mpg.de.
¹³ Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. meissner@molgen.mpg.de.
¹⁴ Center for Personal Dynamic Regulomes, Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. howchang@stanford.edu.
¹⁵ Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. nuria.lopez@irbbarcelona.org.
¹⁶ Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain. nuria.lopez@irbbarcelona.org.
¹⁷ Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain. nuria.lopez@irbbarcelona.org.
¹⁸ Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel. eran.segal@weizmann.ac.il.
¹⁹ Center for Genome Engineering, Institute for Basic Science, Daejon, Republic of Korea. jskim01@snu.ac.kr.

PMID: 32839576
PMCID: PMC7444682
DOI: 10.1038/s41576-020-0272-6

Abstract

In celebration of the 20th anniversary of Nature Reviews Genetics, we asked 12 leading researchers to reflect on the key challenges and opportunities faced by the field of genetics and genomics. Keeping their particular research area in mind, they take stock of the current state of play and emphasize the work that remains to be done over the next few years so that, ultimately, the benefits of genetic and genomic research can be felt by everyone.

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Conflict of interest statement

H.Y.C. is a co-founder of Accent Therapeutics and Boundless Bio and an advisor of 10x Genomics, Arsenal Biosciences and Spring Discovery. J.-S.K. is a co-founder of and holds stock in ToolGen Inc. A.C., A.L.M., A.M., A.W., B.T., E.E.M.F., E.S., N.L.-B., S.G. and S.A.T. declare no competing interests.

References

1. Collins F. The director of the NIH lays out his vision of the future of medical science. Timehttps://time.com/5709207/medical-science-age-of-discovery (2019).
1. The National Academies of Sciences, Engineering, and Medicine Organizing Committee for the International Summit on Human Gene Editing. On human gene editing: international summit statement. The National Academies of Sciences, Engineering, and Medicinehttps://www.nationalacademies.org/news/2015/12/on-human-gene-editing-int... (2015).
1. Centers for Disease Control and Prevention. COVID-19 in racial and ethnic minority groups. CDChttps://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/racial-... (2020).
1. Edwards F, Lee H, Esposito M. Risk of being killed by police use of force in the United States by age, race–ethnicity, and sex. Proc. Natl Acad. Sci. USA. 2019;116:16793–16798. - PMC - PubMed
1. Popejoy AB, Fullerton SM. Genomics is failing on diversity. Nature. 2016;538:161–164. - PMC - PubMed

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The road ahead in genetics and genomics

Affiliations

The road ahead in genetics and genomics

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources