TREM2 activation promotes remyelination

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Heather Wood. Nat Rev Neurol. 2020 Oct.

. 2020 Oct;16(10):522.

doi: 10.1038/s41582-020-0404-9.

No abstract available

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TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, Manis M, Ibrahim A, Deng L, Benitez BA, Cruchaga C, Licastro D, Mihindukulasuriya K, Harari O, Buckland M, Holtzman DM, Rosenthal A, Schwabe T, Tassi I, Piccio L. Cignarella F, et al. Acta Neuropathol. 2020 Oct;140(4):513-534. doi: 10.1007/s00401-020-02193-z. Epub 2020 Aug 9. Acta Neuropathol. 2020. PMID: 32772264 Free PMC article.

1. Cignarella, F. et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathol. https://doi.org/10.1007/s00401-020-02193-z (2020) - DOI - PubMed

1. Ulland, T. K. & Colonna, M. TREM2 — a key player in microglial biology and Alzheimer disease. Nat. Rev. Neurol. 14, 667–675 (2018) - DOI