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. 2020;25(6):507-513.
doi: 10.5863/1551-6776-25.6.507.

Late Acetaminophen Therapy for Patent Ductus Arteriosus in the Preterm Neonate

Ronnelle King, Michael Colon, Laura Stanfel, Kate A Tauber

Late Acetaminophen Therapy for Patent Ductus Arteriosus in the Preterm Neonate

Ronnelle King et al. J Pediatr Pharmacol Ther. 2020.

Abstract

Objective: In preterm infants, the standard pharmacologic treatment for a hemodynamically significant patent ductus arteriosus (hsPDA) is either ibuprofen or indomethacin. However, these medications may be less effective after 2 weeks of age. We investigated the use of acetaminophen in hsPDA closure beyond 2 weeks of age.

Methods: An observational study of 11 infants, <30 weeks' gestation at birth and postnatal age > 2 weeks, who received acetaminophen treatment for their hsPDA. Echocardiograms (ECHOs), B-type natriuretic peptide (BNP) levels, and the fraction of inspired oxygen (FiO2) were obtained before and after treatment to analyze ductal characteristics. Renal and liver functions were monitored pretreatment and posttreatment to look for potential medication side effects.

Results: Of the 10 infants with ECHO data for before and after acetaminophen treatments, 4/10 (40%) had a decrease in PDA size, with no infants having complete closure immediately posttreatment. Eight of 11 (73%) infants had a decreased FiO2 requirement after treatment. Of the 5 infants with pretreatment and posttreatment BNP data, 2/5 (40%) infants had a decrease in BNP level. One infant received an additional course of acetaminophen. Four infants underwent a surgical ligation. Two infants died. No medication side effects occurred with regard to hepatic and renal function.

Conclusion: Acetaminophen is a safe and effective pharmacologic treatment to reduce the significance of the hsPDA in some infants beyond 2 weeks of age, as shown by ECHO and BNP data.

Keywords: acetaminophen; hemodynamically significant PDA; neonate; patent ductus arteriosus.

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Conflict of interest statement

Disclosure The authors declare no conflicts or financial interest in any product of service mentioned in the manuscript. BNP laboratory cartridges were provided by Quidel, Inc. Ronnelle King and Kate Tauber had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Figures

Figure 1.
Figure 1.
Population flow diagram.
Figure 2.
Figure 2.
B-type natriuretic peptide (BNP) levels before and after acetaminophen treatment.
Figure 3.
Figure 3.
Fraction of inspired oxygen (FiO2) requirement before and after acetaminophen treatment.
See this image and copyright information in PMC

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