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Case Reports
. 2020 Nov;5(11):2079-2083.
doi: 10.1016/j.ekir.2020.08.012. Epub 2020 Aug 20.

De Novo ANCA-Associated Vasculitis With Glomerulonephritis in COVID-19

Nupur N Uppal  1 , Nina Kello  2 , Hitesh H Shah  1 , Yuriy Khanin  1 , Ivan Ramirez De Oleo  2 , Edward Epstein  3   4 , Purva Sharma  1 , Christopher P Larsen  5 , Vanesa Bijol  6 , Kenar D Jhaveri  1
Affiliations
Case Reports

De Novo ANCA-Associated Vasculitis With Glomerulonephritis in COVID-19

Nupur N Uppal et al. Kidney Int Rep. 2020 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Kidney biopsy findings. (a) Two glomeruli in the center reveal crescents: a cellular crescent in the glomerulus to the left, and a fibrocellular crescent to the right. Surrounding tubules reveal distension and flattening of the epithelium (periodic acid−Schiff stain, original magnification ×200). (b) Immunofluorescence staining for IgG reveals no significant staining in depicted glomerulus or surrounding tubular basement membranes (fluorescein isothiocyanate, original magnification ×200). (c) Representative section showing negative immunohistochemistry staining for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein after antigen retrieval (original magnification ×200). (d) Lung tissue from a known SARS-CoV-2−infected patient served as positive control for immunohistochemistry method (original magnification ×400).
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention Coronavirus disease 2019 (COVID-19). 2020. https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/summary.html Available at:
    1. Hirsch J.S., Ng J.H., Ross D.W. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int. 2020;98:209–218. - PMC - PubMed
    1. Su H., Yang M., Wan C. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020;98:219–227. - PMC - PubMed
    1. Nasr S.H., Kopp J.B. COVID-19-associated collapsing glomerulopathy: an emerging entity. Kidney Int Rep. 2020;5:759–761. - PMC - PubMed
    1. Jhaveri K.D., Meir L.R., Flores Chang B.S. Thrombotic microangiopathy in a patient with COVID-19. Kidney Int. 2020;98:509–512. - PMC - PubMed

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