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. 2021 Jul 1;73(1):e252-e255.
doi: 10.1093/cid/ciaa1246.

Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients Following Immunomodulatory Therapies

Stefano Busani  1 , Andrea Bedini  2 , Emanuela Biagioni  1 , Lucia Serio  1 , Roberto Tonelli  3 , Marianna Meschiari  2 , Erica Franceschini  2 , Giovanni Guaraldi  2 , Andrea Cossarizza  4 , Enrico Clini  3 , Antonino Maiorana  5 , William Gennari  6 , Nicola De Maria  7 , Mario Luppi  8 , Cristina Mussini  2 , Massimo Girardis  1 ; Modena Covid-19 Working Group (MoCo19)
Collaborators, Affiliations

Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients Following Immunomodulatory Therapies

Stefano Busani et al. Clin Infect Dis. .

Abstract

We report two fatal cases of acute liver failure secondary to herpes simplex virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for and prompt recognition of herpes simplex virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.

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