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Review
. 2020 Nov 10;9(5):596-608.
doi: 10.1093/jpids/piaa099.

A Pediatric Infectious Diseases Perspective of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Novel Coronavirus Disease 2019 (COVID-19) in Children

Andi L Shane  1 , Alice I Sato  2 , Carol Kao  1 , Felice C Adler-Shohet  3 , Surabhi B Vora  4 , Jeffery J Auletta  5 , Sharon Nachman  6 , Vanessa N Raabe  7 , Kengo Inagaki  8 , Ibukunoluwa C Akinboyo  9 , Charles Woods  10 , Abdulsalam O Alsulami  11 , Mundeep K Kainth  12 , Roberto Parulan Santos  13 , Claudia M Espinosa  14 , Julianne E Burns  15 , Coleen K Cunningham  9 , Samuel R Dominguez  16 , Beatriz Larru Martinez  17 , Frank Zhu  18 , Jonathan Crews  19 , Taito Kitano  20 , Lisa Saiman  21 , Karen Kotloff  22
Affiliations
Review

A Pediatric Infectious Diseases Perspective of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Novel Coronavirus Disease 2019 (COVID-19) in Children

Andi L Shane et al. J Pediatric Infect Dis Soc. .

Abstract

Understanding the role that children play in the clinical burden and propagation of severe acute respiratory syndrome coronavirus 2, responsible for coronavirus disease 2019 (COVID-19) infections, is emerging. While the severe manifestations and acute clinical burden of COVID-19 have largely spared children compared with adults, understanding the epidemiology, clinical presentation, diagnostics, management, and prevention opportunities and the social and behavioral impacts on child health is vital. Foremost is clarifying the contribution of asymptomatic and mild infections to transmission within the household and community and the clinical and epidemiologic significance of uncommon severe post-infectious complications. Here, we summarize the current knowledge, identify resources, and outline research opportunities. Pediatric infectious diseases clinicians have a unique opportunity to advocate for the inclusion of children in epidemiological, clinical, treatment, and prevention studies to optimize their care as well as to represent children in the development of guidance and policy during pandemic response.

Keywords: COVID-19; SARS-CoV-2; children; novel coronavirus; pediatrics.

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