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Review
. 2020 Oct 7;28(10):2108-2110.
doi: 10.1016/j.ymthe.2020.08.011. Epub 2020 Aug 25.

Senolytic CAR T Cells in Solid Tumors and Age-Related Pathologies

Judith Feucht  1 , Mohamed Abou-El-Enein  2
Affiliations
Review

Senolytic CAR T Cells in Solid Tumors and Age-Related Pathologies

Judith Feucht et al. Mol Ther. .
No abstract available

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Figures

Figure 1
Figure 1
Senolytic CAR T Cells in Age-Related Pathologies and Solid Tumors (A) Age-related pathologies and (B) solid malignant tumors. Senolytic CAR T cells migrate to the areas of senescence and infiltrate the senescent tissues. The binding of the CAR to the target antigen expressed on senescent cells (e.g., uPAR) triggers an intracellular signaling cascade that elicits T cell activation, proliferation, and effector functions, resulting in the lysis of senescent cells. Elimination of senescent cells may subsequently restore tissue homeostasis and function.
See this image and copyright information in PMC

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