Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov:132:104064.
doi: 10.1016/j.mvr.2020.104064. Epub 2020 Aug 22.

Sublingual microcirculation in patients with SARS-CoV-2 undergoing veno-venous extracorporeal membrane oxygenation

Andrea Carsetti  1 , Elisa Damiani  2 , Erika Casarotta  2 , Claudia Scorcella  3 , Roberta Domizi  3 , Jonathan Montomoli  2 , Francesco Gasparri  3 , Vincenzo Gabbanelli  3 , Simona Pantanetti  3 , Roberto Carozza  4 , Erica Adrario  1 , Abele Donati  5
Affiliations

Sublingual microcirculation in patients with SARS-CoV-2 undergoing veno-venous extracorporeal membrane oxygenation

Andrea Carsetti et al. Microvasc Res. 2020 Nov.

Abstract

Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) is a rescue treatment for severe acute respiratory failure refractory to conventional ventilation. We examined the alterations of sublingual microcirculation in patients with SARS-CoV-2 during VV-ECMO treatment and assessed the relationship between microvascular parameters and ventilation, hemodynamics, and laboratory tests. Nine patients were included in the study and the following microcirculatory parameters were estimated: TVD 16.81 (14.46-18.6) mm/mm2; PVD 15.3 (14.09-17.96) mm/mm2; PPV 94.85% (93.82%-97.79%); MFI 2.5 (2.5-2.92); HI 0.4 (0.18-0.4). TVD and PVD were inversely related to D-dimer levels (rho = -0.667, p = 0.05 and rho = -0.733, p = 0.025 respectively), aspartate aminotransferase (AST) (rho = -0.886, p = 0.019 and rho = -0.886, p = 0.019 respectively) and alanine aminotransferase (ALT) (rho = -0.829, p = 0.042 and rho = -0.829, p = 0.042 respectively). Our results showed an altered sublingual microcirculation in patients receiving VV-ECMO for severe SARS-CoV-2 and suggest a potential contribution of endothelia dysfunction to determine microvascular alteration.

Keywords: Extracorporeal membrane oxygenation; Microcirculation; SARS-CoV-2.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

    1. Angstwurm M.W.A., Reininger A.J., Spannagl M. D-Dimer as marker for microcirculatory failure: correlation with LOD and APACHE II scores. Thromb. Res. 2004;113:353–359. doi: 10.1016/j.thromres.2004.03.013. - DOI - PubMed
    1. Damiani E., Carsetti A., Casarotta E., Scorcella C., Domizi R., Adrario E., Donati A. Microvascular alterations in patients with SARS-COV-2 severe pneumonia. Ann. Intensive Care. 2020 doi: 10.1186/s13613-020-00680-w. - DOI - PMC - PubMed
    1. Guven G., Hilty M.P., Ince C. Microcirculation: physiology, pathophysiology, and clinical application. Blood Purif. 2020 doi: 10.1159/000503775. - DOI - PMC - PubMed
    1. Iba T., Levy J.H., Connors J.M., Warkentin T.E., Thachil J., Levi M. The unique characteristics of COVID-19 coagulopathy. Crit. Care. 2020 doi: 10.1186/s13054-020-03077-0. - DOI - PMC - PubMed
    1. Jung F., Krüger-Genge A., Franke R.P., Hufert F., Küpper J.-H. COVID-19 and the endothelium. Clin. Hemorheol. Microcirc. 2020 doi: 10.3233/CH-209007. - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources