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Comment
. 2020 Oct;98(9):709-711.
doi: 10.1111/imcb.12391. Epub 2020 Aug 25.

Senolytic chimeric antigen receptor (CAR) T cell: driving the immune system to fight cell senescence

Karina L Hajdu  1 , Martín H Bonamino  1   2
Affiliations
Comment

Senolytic chimeric antigen receptor (CAR) T cell: driving the immune system to fight cell senescence

Karina L Hajdu et al. Immunol Cell Biol. 2020 Oct.

Abstract

We discuss in this News and Commentary article the implications of senolytic chimeric antigen receptor T cells.

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Comment on

  • Senolytic CAR T cells reverse senescence-associated pathologies.
    Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW. Amor C, et al. Nature. 2020 Jul;583(7814):127-132. doi: 10.1038/s41586-020-2403-9. Epub 2020 Jun 17. Nature. 2020. PMID: 32555459 Free PMC article.

References

REFERENCES

    1. Amor C, Feucht J, Leibold J, et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature 2020; 583: 127-132.
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    1. Campisi J. Aging, cellular senescence, and cancer. Ann Rev Physiol 2013; 75: 685-705.

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