Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Aug 23;12(9):2551.
doi: 10.3390/nu12092551.

Influence of Enteral Nutrition on Gut Microbiota Composition in Patients with Crohn's Disease: A Systematic Review

Paulina Horwat  1 , Stanisław Kopeć  1 , Aleksandra Garczyk  1 , Iwona Kaliciak  1 , Zuzanna Staręga  1 , Konstanty Drogowski  1 , Marcin Mardas  2 , Marta Stelmach-Mardas  1
Affiliations

Influence of Enteral Nutrition on Gut Microbiota Composition in Patients with Crohn's Disease: A Systematic Review

Paulina Horwat et al. Nutrients. .

Abstract

The aim of the study was to systematically and comprehensively evaluate whether exclusive enteral nutrition (EEN) has impact on gut microbiota in patients with Crohn's disease (CD). The databases PUBMED (MEDLINE), SCOPUS and WEB OF SCIENCE were searched. Out of 232 studies, 9 met inclusion criteria. The combined analyzed population consists of 118 patients with CD and treated with EEN with a time of intervention of 2-12 weeks. Studies were conducted in children, with the exception of one study. All applied feeding formulas had similar energy value and composition. The microbiome analysis was based on 16S rRNA gene sequencing of faecal samples. In all studies, EEN treatment decreases inflammatory markers (i.e., hs-CRP and FCP). A change in abundance of numerous bacterial families (Clostridiaceae, Eubacteriaceae, Bacteroidaceae) was noticed, especially in Bacteroidaceae. An increase in families connected to the more severe clinical course (Fusobacteria, Prevotella, Lachnospiraceae) was observed in only 2.5% of CD patients. Our analyses suggest EEN has a beneficial influence on gut microbiome in patients with CD, which is interrelated with clinical patient's improvement and time of disease remission.

Keywords: inflammatory bowel disease; malnutrition; nutrition; time of remission.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the databases search on the changes in the gut microbiota during exclusive enteral nutrition treatment.
See this image and copyright information in PMC

References

    1. Ananthakrishnan A.N. Epidemiology and risk factors for IBD. Nat. Rev. Gastroenterol. Hepatol. 2015;12:205–217. doi: 10.1038/nrgastro.2015.34. - DOI - PubMed
    1. Lee D., Albenberg L., Compher C., Baldassano R., Piccoli D., Lewis J.D., Wu G.D. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology. 2015;148:1087–1106. doi: 10.1053/j.gastro.2015.01.007. - DOI - PMC - PubMed
    1. Sigall-Boneh R., Levine A., Lomer M., Wierdsma N., Allan P., Fiorino G., Gatti S., Jonkers D., Kierkus J., Katsanos K.H., et al. Research Gaps in Diet and Nutrition in Inflammatory Bowel Disease. A Topical Review by D-ECCO Working Group [Dietitians of ECCO] J. Crohn’s Colitis. 2017;11:1407–1419. doi: 10.1093/ecco-jcc/jjx109. - DOI - PubMed
    1. Ashton J.J., Colquhoun C.M., Cleary D.W., Coelho T., Haggarty R., Mulder I., Batra A., Afzal N.A., Beattie R.M., Scott K.P., et al. 16S sequencing and functional analysis of the fecal microbiome during treatment of newly diagnosed pediatric inflammatory bowel disease. Medicine. 2017;96:e7347. doi: 10.1097/MD.0000000000007347. - DOI - PMC - PubMed
    1. Donnellan C.F., Yann L.H., Lal S. Nutritional management of Crohn’s disease. Ther. Adv. Gastroenterol. 2013;6:231–242. doi: 10.1177/1756283X13477715. - DOI - PMC - PubMed

Publication types

MeSH terms