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Case Reports
. 2020 Aug 24;13(8):e237043.
doi: 10.1136/bcr-2020-237043.

Apixaban-induced cutaneous leucocytoclastic vasculitis

Munim Khan  1 , Mahmoud Y Madi  2 , Joseph Rencic  3
Affiliations
Case Reports

Apixaban-induced cutaneous leucocytoclastic vasculitis

Munim Khan et al. BMJ Case Rep. .
No abstract available

Keywords: dermatology; pathology; pharmacology and therapeutics.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Diffuse palpable tender non-blanching violaceous coalescent macules and patches are noted on both thighs and calves.
Figure 2
Figure 2
High-magnification H&E staining of a punch biopsy of the rash showing the classical histological findings of leucocytoclastic vasculitis including vascular damage by the nuclear debri of infiltrating neutrophils with fibrinoid necrosis (green arrow) and red cell extravasation (blue arrow) in the dermis.
See this image and copyright information in PMC

References

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    1. Chaaya G, Jaller-Char J, Ghaffar E, et al. . Rivaroxaban-induced leukocytoclastic vasculitis: a challenging rash. Ann Allergy Asthma Immunol 2016;116:577–8. 10.1016/j.anai.2016.03.012 - DOI - PubMed
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    1. Dean R, Messer AM, Pickett M, et al. . A case of leukocytoclastic vasculitis caused by novel anticoagulant rivaroxaban. Dermatol Online J 2017;23. [Epub ahead of print: 15 Nov 2017]. - PubMed

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