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Case Reports
. 2020 Aug 24;13(8):e233135.
doi: 10.1136/bcr-2019-233135.

Faecal microbiota transplantation (FMT) with dietary therapy for acute severe ulcerative colitis

Samuel Paul Costello  1   2 , Alice Day  3   2 , Chu K Yao  4 , Robert Venning Bryant  3   2
Affiliations
Case Reports

Faecal microbiota transplantation (FMT) with dietary therapy for acute severe ulcerative colitis

Samuel Paul Costello et al. BMJ Case Rep. .

Abstract

A 19-year-old man presented with acute severe ulcerative colitis. He was taking azathioprine (therapeutic metabolites) and sulphasalazine as well as infliximab with a therapeutic drug level. On day 3 of hydrocortisone therapy, he met day Oxford criteria with >8 bloody stools per day and was given faecal microbiota transplantation and subsequently commenced on dietary therapy combining several strategies-(1) increased intake of fermentable fibres, (2) reduced intake of overall and sulfur-containing protein and (3) restriction of sulfate and sulfite food additives. At week 8 assessment, he was in clinical and endoscopic remission and remained in clinical and endoscopic remission at 12 months.

Keywords: gastrointestinal system; ulcerative colitis.

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Conflict of interest statement

Competing interests: SPC reports support from Janssen, Shire, Ferring, Microbiotica and Pfizer. RVB has recieved research support from AbbVie, Emerge Health, Ferring, Janssen, Shire, and Takeda.

Figures

Figure 1
Figure 1
Sigmoid colon at week 0 (prior to faecal microbiota transplantation and dietary therapy).
Figure 2
Figure 2
Sigmoid colon at week 8 post faecal microbiota transplantation and dietary therapy.
Figure 3
Figure 3
Sigmoid colon at 12 months post faecal microbiota transplantation and dietary therapy.
See this image and copyright information in PMC

References

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