Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Aug 25;5(1):170.
doi: 10.1038/s41392-020-00287-4.

Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

Affiliations
Comment

Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

Francesca Fagiani et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Representation of “reverse vaccinology 2.0” theory: focus on the molecular features of IGHV3-53-encoded antibodies. Monoclonal antibodies are obtained from seropositive subjects, isolated and structurally characterized. Based on the molecular features, a structure-based immunogen is designed and then tested in appropriate animal models

Comment on

  • Structural basis of a shared antibody response to SARS-CoV-2.
    Yuan M, Liu H, Wu NC, Lee CD, Zhu X, Zhao F, Huang D, Yu W, Hua Y, Tien H, Rogers TF, Landais E, Sok D, Jardine JG, Burton DR, Wilson IA. Yuan M, et al. Science. 2020 Aug 28;369(6507):1119-1123. doi: 10.1126/science.abd2321. Epub 2020 Jul 13. Science. 2020. PMID: 32661058 Free PMC article.

References

    1. Yuan, M. et al. Structural basis of a shared antibody response to SARS-CoV-2. Science10.1126/science.abd2321 (2020). - PMC - PubMed
    1. Burton DR. What are the most powerful immunogen design vaccine strategies? Reverse vaccinology 2.0 shows great promise. Cold Spring Harb. Perspect. Biol. 2017;9:a030262. doi: 10.1101/cshperspect.a030262. - DOI - PMC - PubMed
    1. Hoffmann M, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271–280.e8. doi: 10.1016/j.cell.2020.02.052. - DOI - PMC - PubMed
    1. Rogers, T. F. et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science10.1126/science.abc7520 (2020). - PMC - PubMed
    1. Ju, B. et al. Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature10.1038/s41586-020-2380-z (2020). - PubMed

Publication types