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Comment
. 2020 Aug 25;5(1):167.
doi: 10.1038/s41392-020-00272-x.

Human-viral chimera: a novel protein affecting viral virulence and driving host T-cell immunity

Zhenling Wang  1 , Li Zhang  2 , Min Wu  3   4
Affiliations
Comment

Human-viral chimera: a novel protein affecting viral virulence and driving host T-cell immunity

Zhenling Wang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The chimeric proteins produced by the novel mechanism activate T-cell responses and affect virulence. a The synthesis of influenza A virus (IAV) mRNA; b The formation of host-viral chimeric proteins in the presence of upstream AUGs (uAUGs); c Host-virus protein chimeras are recognized by T cells and affect virulence in mice.
See this image and copyright information in PMC

Comment on

  • Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection.
    Ho JSY, Angel M, Ma Y, Sloan E, Wang G, Martinez-Romero C, Alenquer M, Roudko V, Chung L, Zheng S, Chang M, Fstkchyan Y, Clohisey S, Dinan AM, Gibbs J, Gifford R, Shen R, Gu Q, Irigoyen N, Campisi L, Huang C, Zhao N, Jones JD, van Knippenberg I, Zhu Z, Moshkina N, Meyer L, Noel J, Peralta Z, Rezelj V, Kaake R, Rosenberg B, Wang B, Wei J, Paessler S, Wise HM, Johnson J, Vannini A, Amorim MJ, Baillie JK, Miraldi ER, Benner C, Brierley I, Digard P, Łuksza M, Firth AE, Krogan N, Greenbaum BD, MacLeod MK, van Bakel H, Garcìa-Sastre A, Yewdell JW, Hutchinson E, Marazzi I. Ho JSY, et al. Cell. 2020 Jun 25;181(7):1502-1517.e23. doi: 10.1016/j.cell.2020.05.035. Epub 2020 Jun 18. Cell. 2020. PMID: 32559462 Free PMC article.

References

    1. Ho JSY, et al. Hybrid gene origination creates human-virus chimeric proteins during infection. Cell. 2020;181:1–16. doi: 10.1016/j.cell.2020.05.035. - DOI - PMC - PubMed
    1. Rialdi A, et al. The RNA exosome syncs IAV-RNAPII transcription to promote viral ribogenesis and infectivity. Cell. 2017;169:679–692. doi: 10.1016/j.cell.2017.04.021. - DOI - PMC - PubMed
    1. Zhang Y, et al. Influenza research database: an integrated bioinformatics resource for influenza virus research. Nucleic Acids Res. 2017;45:D466–D474. doi: 10.1093/nar/gkw857. - DOI - PMC - PubMed
    1. Lipford GB, Hoffman M, Wagner H, Heeg K. Primary in vivo responses to ovalbumin. Probing the predictive value of the Kb binding motif. J. Immunol. 1993;150:1212–1222. - PubMed
    1. Wallat GD, et al. High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase in complex with magnesium ions. PLoS ONE. 2014;9:e87577. doi: 10.1371/journal.pone.0087577. - DOI - PMC - PubMed

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